RESUMEN

PTLD is a serious and frequently observed complication after solid organ transplantation. We present a six-yr-old girl with a rapidly growing, solid tumor of the lip four yr after orthotopic heart transplantation, which was classified as monomorphic PTLD with the characteristics of a diffuse large B-cell lymphoma. Treatment with reduction in immunosuppression, ganciclovir, and anti B-cell monoclonal antibody (rituximab) resulted in full remission since 12 months. To the best of our knowledge, this report is the first description of PTLD in the lip in a pediatric patient after heart transplantation in the English literature.

Asunto(s)

Cardiomiopatías/terapia , Insuficiencia Cardíaca/terapia , Trasplante de Corazón/efectos adversos , Neoplasias de los Labios/etiología , Labio/inmunología , Linfoma de Células B/complicaciones , Trastornos Linfoproliferativos/diagnóstico , Anticuerpos Monoclonales de Origen Murino/farmacología , Cardiomiopatías/complicaciones , Niño , Infecciones por Virus de Epstein-Barr/complicaciones , Infecciones por Virus de Epstein-Barr/diagnóstico , Femenino , Ganciclovir/farmacología , Insuficiencia Cardíaca/complicaciones , Herpesvirus Humano 4/metabolismo , Humanos , Inmunosupresores/farmacología , Neoplasias de los Labios/terapia , Linfoma de Células B/terapia , Trastornos Linfoproliferativos/complicaciones , Complicaciones Posoperatorias , Inducción de Remisión , Rituximab , Factores de Tiempo