RESUMEN
The use of zero-order and first-derivative flame emission spectrometry has been investigated for the determination of basal concentrations of lithium in serum and urine at the microgram dm-3 level. No significant matrix effect was observed; however, it was necessary to make use of background correction techniques. Two or three wavelength measurements and first-derivative spectrometry were used for this purpose; both methods gave similar results. Detection limits for serum of approximately 0.09 micrograms dm-3 were found by both zero-order and first-derivative emission measurements, while normal lithium levels were found to be 29.3 and 1.17 micrograms dm-3 for urine and serum, respectively.
Asunto(s)
Litio/análisis , Humanos , Litio/sangre , Litio/orina , Microquímica/métodos , Valores de Referencia , Espectrofotometría Atómica/métodos , Análisis Espectral/métodosRESUMEN
A rapid and simple method for the simultaneous determination of trifluoperazine dihydrochloride and tranylcypromine sulphate by first- and fourth-derivative UV spectrophotometry is presented. The procedure consists of extraction in 0.2 m hydrochloric acid, filtration and measurement of the amplitudes of the first- and fourth-derivative spectra at 260 and 274 nm, respectively. A zero-crossing technique is used for the determination of trifluoperazine. Good linearity, accuracy, precision and selectivity were found, and the method is proposed for routine quality control purposes, even for the uniformity of contents test.