RESUMEN

Highly pathogenic avian influenza (HPAI) A(H5N1) viruses have been circulating since 2003 in Indonesia, with major impacts on poultry health, severe economic losses, and 168 fatal laboratory-confirmed human cases. We performed phylogenetic analysis on 39 full-genome H5N1 virus samples collected during outbreaks among poultry in 2015-2016 in West Java and compared them with recently published sequences from Indonesia. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to 2 genetic groups in clade 2.3.2.1c. We also observed these groups for the neuraminidase, nucleoprotein, polymerase, and polymerase basic 1 genes. Matrix, nonstructural protein, and polymerase basic 2 genes of some HPAI were most closely related to clade 2.1.3 instead of clade 2.3.2.1c, and a polymerase basic 2 gene was most closely related to Eurasian low pathogenicity avian influenza. Our results detected a total of 13 reassortment types among HPAI in Indonesia, mostly in backyard chickens in Indramayu.

Asunto(s)

Subtipo H5N1 del Virus de la Influenza A/genética , Gripe Aviar/epidemiología , Gripe Aviar/virología , Enfermedades de las Aves de Corral/epidemiología , Enfermedades de las Aves de Corral/virología , Virus Reordenados/genética , Secuencia de Aminoácidos , Animales , Brotes de Enfermedades , Genotipo , Glicoproteínas Hemaglutininas del Virus de la Influenza/genética , Humanos , Indonesia/epidemiología , Subtipo H5N1 del Virus de la Influenza A/clasificación , Filogenia , Aves de Corral , Vigilancia en Salud Pública , Virus Reordenados/clasificación , Análisis de Secuencia de ADN