RESUMEN
A treatment modality employing radiotherapy with subsequent hyperglycemia induction was evolved in experiments on mice and then clinically tested in 32 cases of inoperable locally--extensive primary and recurrent cancer of the rectum. A 50% regression of tumor was registered in 14 (43.0%) out of 32 patients treated with radiotherapy in combination with hyperglycemia. Similar degree of regression was observed only in 6 (15.0%) out of 40 patients who received the same radiation treatment unaccompanied by hyperglycemia. The difference was statistically significant. No untoward side--effects developed. The results are encouraging and seem to open up new vistas of clinical research.
Asunto(s)
Adenocarcinoma/radioterapia , Glucemia/fisiología , Glucosa , Fármacos Sensibilizantes a Radiaciones , Neoplasias del Recto/radioterapia , Adenocarcinoma/sangre , Adulto , Anciano , Animales , Carcinoma de Ehrlich/radioterapia , Terapia Combinada , Humanos , Masculino , Ratones , Persona de Mediana Edad , Neoplasias del Recto/sangreRESUMEN
The authors give an experimental evaluation of the appropriateness of the use of short-term hyperglycemia combined with hypoxiradiotherapy of solid tumors. In comparing the response of tumors and overlying skin a conclusion has been made that gaseous hypoxia and the use of hyperglycemia separately yield in a considerable therapeutic benefit, and the use of the combination of these agents in some cases produces a greater therapeutic interval between tumor destruction and normal tissues. The mechanisms of the modification of radiation injuries of tumors and skin under the influence of the above two factors are discussed.
Asunto(s)
Glucemia/metabolismo , Carcinoma de Ehrlich/radioterapia , Oxígeno/farmacología , Tolerancia a Radiación , Animales , Carcinoma de Ehrlich/sangre , Carcinoma de Ehrlich/patología , División Celular/efectos de la radiación , Glucosa/farmacología , Masculino , Ratones , Consumo de Oxígeno , Traumatismos Experimentales por Radiación/metabolismo , Traumatismos Experimentales por Radiación/prevención & control , Dosificación Radioterapéutica , Piel/metabolismo , Piel/efectos de la radiaciónAsunto(s)
Carcinoma de Ehrlich/radioterapia , Hiperglucemia/fisiopatología , Animales , Carcinoma de Ehrlich/fisiopatología , Hipoxia/fisiopatología , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Trasplante de Neoplasias , Terapia por Inhalación de Oxígeno , Tolerancia a Radiación , Factores de TiempoRESUMEN
In rats were Heren carcinoma at the initial stage of hypothermia (30-31 degrees C) in hepatic tissues there was observed at a greater intensity of protein and nucleic acids synthesis contrary to its marked reduction in tumor tissues. In tumor tissues a cessation of protein synthesis was observed at 20-21 degrees C. while that of nucleic acids at 14-15 degrees C. Under these regimens of hypothermia no complete cessation of protein and nucleic acids synthesis in hepatic tissue occurred. However, their synthesis was markedly suppressed.