RESUMEN
BACKGROUND: Seborrheic dermatitis (SD) is a chronic mild skin disorder with high prevalence. Various treatment options are available, including topical antifungals and anti-inflammatories. Antifungal and anti-inflammatory properties of Quassia amara have been reported. AIM: To check the efficacy and safety of a topical gel with 4% Quassia amara extract and compare it with topical 2% ketoconazole and 1% topical ciclopiroxolamine in the treatment of facial SD. METHODS: A group of 60 patients displaying facial SD were randomly distributed in 3 groups and given either a topical gel with 4% Quassia amara extract, a topical gel with 2% ketoconazole, or a topical gel with 1% ciclopirox olamine for 4 weeks. Disease severity was assessed at the start and weekly along treatment, as well as 4 weeks after the end of treatment. In each selected area, severity of erythema, scaling, pruritus, and papules were scored from 0 to 3, the sum of these values representing the score of SD on the face. This evaluation was conducted at each visit. The decrease in SD score with all 3 products was compared at each visit. At each stage, overall improvement, safety, and tolerability were also assessed. RESULTS: Of the 60 patients, 54 (90%) completed the study. The 3 therapeutic options resulted to be very effective, with a significant advantage in efficacy for 4% Quassia extract. For the other 2 drugs, the results were in line with those previously published in the literature. CONCLUSION: Topical gel with 4% Quassia extract represents a new, safe, and effective treatment for facial SD.
Asunto(s)
Antifúngicos/uso terapéutico , Dermatitis Seborreica/tratamiento farmacológico , Extractos Vegetales/uso terapéutico , Quassia/química , Administración Cutánea , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Antifúngicos/administración & dosificación , Antifúngicos/efectos adversos , Ciclopirox , Dermatitis Seborreica/patología , Método Doble Ciego , Dermatosis Facial/tratamiento farmacológico , Dermatosis Facial/patología , Femenino , Geles , Humanos , Cetoconazol/administración & dosificación , Cetoconazol/uso terapéutico , Masculino , Persona de Mediana Edad , Extractos Vegetales/administración & dosificación , Extractos Vegetales/efectos adversos , Piridonas/administración & dosificación , Piridonas/uso terapéutico , Adulto JovenRESUMEN
BACKGROUND: There are various treatment options available for rosacea, depending on the subtype, but treatment is still generally unsatisfactory. Some studies have reported antiparasitic and anti-inflammatory properties of Quassia amara. AIM: To check the efficacy and safety of a topical gel with 4% Quassia amara extract in the treatment of various grades of rosacea. METHODS: A group of 30 patients with various grades of rosacea (I-IV) were investigated in a single-center, open-label study. They were treated with a topical gel with 4% Quassia amara extract for 6 weeks. Response was evaluated by the flushing, erythema, telangiectasia, papules, and pustules scores. At the end of therapy, overall improvement, safety, and tolerability were assessed. RESULTS: Twenty-seven of 30 patients (90%) completed the study. The treatment resulted to be very effective, and the results achieved were in line with those published with topical metronidazole and azelaic acid. Safety and tolerability were excellent. CONCLUSION: Topical quassia extract could be a new, efficient, and safe weapon in the armamentarium for the management of rosacea.
Asunto(s)
Extractos Vegetales/uso terapéutico , Quassia , Rosácea/tratamiento farmacológico , Administración Tópica , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Geles , Humanos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento , Adulto JovenRESUMEN
The primary objective of the study was to evaluate the antipruritic effect of natural superoxide dismutase in the cosmetic product Sodermix cream. In this randomized intra-individual study including 15 volunteers, 14 female and one male, mean age 41 +/- 4 (range 18-66) years, the cosmetic product Sodermix cream was evaluated according to the Dermscan Group protocol by recording thermal sensitivity levels using Cutaneous Thermal Sensitivity analyzer before and 30 and 90 minutes after the product application. The study was conducted from April to June 2008. Study results showed a decrease in the lengths of pruritus 30 minutes of the product application onto the treated zone and a significant decrease in pruritus intensity 90 minutes of the product application onto the treated zone. The study allows for evaluation of physical sensation and quantification of heat with cutaneous thermal sensitivity measurements as a psycho-physical method to evaluate variables of thermal sensations in relation to variables by thermal stimuli. The study demonstrated a significant antipruritic effect of Sodermix cream.
Asunto(s)
Prurito/tratamiento farmacológico , Superóxido Dismutasa/uso terapéutico , Adolescente , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pomadas , Piel/efectos de los fármacos , Superóxido Dismutasa/administración & dosificación , Sensación Térmica/efectos de los fármacos , Factores de Tiempo , Resultado del TratamientoRESUMEN
In humans, as in all mammals and most chordates, three forms of superoxide dismutase (SOD) are present: SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. SOD is used in cosmetic products to reduce free radical damage to the skin, for example, to reduce fibrosis following radiation for breast cancer. Pruritus is one of the most common symptoms of skin diseases, but can also be a major symptom of systemic diseases (e.g., malignancy, infection or metabolic disorders). There are various antihistaminics used as antipruritogenic substances. In the genesis of pruritus there are many pruritogens involved, not only histamine and leukotrienes such as acetylcholine, cytokines, kallikreins, proteases, kinins, opioids, etc., which are described. On many occasions, we observed that topical SOD seemed to possess strong antipruritic activity, even in anti-histamine-resistant pruritus. We analyzed literature data on the effect of SOD as an anti-pruritogen on NK-1 receptors and proinflammatory cytokines, its regulatory role in calcitonin gene-related peptide production and expression, down-regulation of TNF- and numerous cytokines, and suppression of nitric oxide production.