RESUMEN
The dichloromethane extract of Plectranthus ornatus Codd., a tradicional medicinal plant, showed antibiotic activity with minimum inhibitory concentration (MIC) values of 0.4 mg.mL-1 and 100 percent of biofilm inhibition against Staphylococcus aureus strains isolated from animals with mastitis infections. Based on these antibacterial activities, in addition to ethnopharmacological reports from healing men and farmers in Brazil, an herbal soap was produced from this active extract and was tested both in vitro and in vivo. In vivo assays conducted on these herbal soaps led to results similar to those previously conducted with the active extract. These results indicated the great potential of this plant for use as an excipient by preparing herbal antibacterial soaps as an alternative veterinary medicine aimed at controlling bovine mastitis infections on small Brazilian farms.
Asunto(s)
Antibacterianos/farmacología , Extractos Vegetales/farmacología , Plantas Medicinales/química , Plectranthus/química , Staphylococcus aureus/efectos de los fármacos , Animales , Bovinos , Mastitis Bovina/microbiología , Pruebas de Sensibilidad Microbiana , Plantas Medicinales/clasificación , Plectranthus/clasificación , Staphylococcus aureus/aislamiento & purificaciónRESUMEN
ABSTRACT The dichloromethane extract of Plectranthus ornatus Codd., a tradicional medicinal plant, showed antibiotic activity with minimum inhibitory concentration (MIC) values of 0.4 mg.mL-1 and 100 percent of biofilm inhibition against Staphylococcus aureus strains isolated from animals with mastitis infections. Based on these antibacterial activities, in addition to ethnopharmacological reports from healing men and farmers in Brazil, an herbal soap was produced from this active extract and was tested both in vitro and in vivo. In vivo assays conducted on these herbal soaps led to results similar to those previously conducted with the active extract. These results indicated the great potential of this plant for use as an excipient by preparing herbal antibacterial soaps as an alternative veterinary medicine aimed at controlling bovine mastitis infections on small Brazilian farms.
Asunto(s)
Animales , Plantas Medicinales/química , Staphylococcus aureus/efectos de los fármacos , Extractos Vegetales/farmacología , Plectranthus/química , Antibacterianos/farmacología , Plantas Medicinales/clasificación , Staphylococcus aureus/aislamiento & purificación , Bovinos , Pruebas de Sensibilidad Microbiana , Plectranthus/clasificación , Mastitis BovinaRESUMEN
(-)-Cytoxazone, originally isolated from cultures of a Streptomyces species has an oxazolidin-2-one 4,5-disubstituted ring. It is known that this natural product presents a cytokine modulator effect through the signaling pathway of Th2 cells (type 2 cytokines), which are involved in the process of growth and differentiation of cells. From this, the interest in the development of research aimed at the total synthesis of this molecule and its analogs has remained high, which can be confirmed by the large number of publications on the topic, more than 30 to date. This review focuses on the various creative methods for the synthesis of (-)-cytoxazone and its congeners. The assessment of the preparation of this oxazolidinone and related structures serves as a treatise on the efforts made in the synthesis of this important class of compound from its first total synthesis in 1999.
Asunto(s)
Citocinas/metabolismo , Oxazoles , Transducción de Señal/efectos de los fármacos , Células Th2/metabolismo , Animales , Humanos , Oxazoles/síntesis química , Oxazoles/química , Oxazoles/farmacologíaRESUMEN
Upon undergoing biomonitoring, the most active dichloromethane extract retrieved from Senna macranthera roots led to the isolation of three main compounds: emodine, physione, and chrysophanol. In this sequence, these compounds revealed a potential antibacterial activity against Staphylococcus aureus strains isolated from animals with mastitis infections with minimum inhibitory concentration (MIC) values of 20, 90, and 90 µg mL(-1), respectively. Therefore, an herbal soap was also produced from this same active extract. This soap was tested in vitro using gloves contaminated by animals with bovine mastitis that had been discarded after use by milkers and showed similar results to previously tested compounds. These results indicate the potential of this plant as an alternative veterinary medicine for the production of antibacterial soaps that aimed at controlling bovine mastitis infections in small Brazilian farms.
RESUMEN
An interesting new approach was developed for the synthesis of Evans' chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from animals with mastitis infections.
Asunto(s)
Antibacterianos/síntesis química , Antibacterianos/farmacología , Oxazolidinonas/síntesis química , Oxazolidinonas/farmacología , Animales , Antibacterianos/química , Bovinos , Femenino , Mastitis Bovina/microbiología , Oxazolidinonas/química , Staphylococcus aureus/efectos de los fármacos , EstereoisomerismoRESUMEN
The bioassay-guided isolation of the active extract of Salvinia auriculata Aubl. led to the separation of three main compounds, characterized as stigmasterone, stigmasterol, and friedelinol. The pure form of diketosteroid presented a potential antibacterial activity with a minimum inhibitory concentration (MIC) value of 0.01 mg mL(-1) against Staphylococcus aureus isolated from animals with mastitis infections. The active extract also showed a similar result to that previously obtained with pure diketosteroid when tested with the same isolates. The present study's results demonstrate the potential of this plant as an excipient for the production of antibacterial soaps aimed at controlling bovine mastitis infections, especially on small farms.
RESUMEN
Extratos de acetato de etila obtidos dos fungos fitopatogênicos Diplodia maydis e Sclerotium rolfsii mostraram atividade bactericida contra bactérias multi droga resistentes isoladas de pacientes de Hospital Brasileiro.