Asunto(s)
Técnica del Anticuerpo Fluorescente , Linfoma/diagnóstico , Neoplasias Gástricas/diagnóstico , Anticuerpos Monoclonales , Histocitoquímica , Humanos , Cadenas kappa de Inmunoglobulina/análisis , Cadenas lambda de Inmunoglobulina/análisis , Linfoma/inmunología , Linfoma/patología , Masculino , Persona de Mediana Edad , Neoplasias Gástricas/inmunología , Neoplasias Gástricas/patologíaRESUMEN
Ketanserin is a pure antagonist of serotonin S2-receptors, in blood vessels, platelets and bronchial tissue. Ketanserin has been suggested as hypotensive drug in man, but it shows as well a specific activity on platelet aggregation. An increased incidence of hypertension, of unknown origin, has been found in patients with chronic alcoholism: hypotheses have been made upon an increased incretion of catecholamines and a greater sensitivity of blood vessels' receptors to their action. The data from the present study of eleven patients show that these subjects had an increased platelet activity and ketanserin administration was effective in allowing both the blood pressure levels and platelet activity to resume their normal range. This drug is thus suggested, for its pharmacological properties, as an elective medication for hypertensive patients with chronic alcoholism.
Asunto(s)
Alcoholismo/complicaciones , Antihipertensivos/uso terapéutico , Hipertensión/tratamiento farmacológico , Piperidinas/uso terapéutico , Adulto , Antihipertensivos/efectos adversos , Presión Sanguínea/efectos de los fármacos , Femenino , Humanos , Hipertensión/complicaciones , Ketanserina , Masculino , Persona de Mediana Edad , Piperidinas/efectos adversos , Factores de TiempoRESUMEN
Ketanserin is a pure and selective antagonist of serotonin S2-receptors in blood vessels, platelets and bronchial tissue. It antagonizes serotonin-induced vasoconstriction, bronchoconstriction and platelet aggregation, and indirectly it blocks platelet release reaction. Ketanserin has little or no effect on healthy subjects. Serotonin-induced or serotonin-potentiated platelet aggregation is inhibited in blood drawn from ketanserin-treated healthy volunteers. Oral or parenteral ketanserin treatment did not cause major changes in beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) plasma concentrations, when basic values were normal. Increased microaggregate formation was found in alcoholics and heavy drinkers. It was also found that beta-TG and PF4 levels were higher in these patients than in the controls. Ketanserin treatment tended to normalize these protein levels in such patients.