Asunto(s)
Glomeruloesclerosis Focal y Segmentaria/inmunología , Inmunoglobulina M/análisis , Riñón/inmunología , Síndrome Nefrótico/inmunología , Adolescente , Adulto , Biopsia , Niño , Preescolar , Resistencia a Medicamentos , Femenino , Técnica del Anticuerpo Fluorescente , Glomeruloesclerosis Focal y Segmentaria/tratamiento farmacológico , Glomeruloesclerosis Focal y Segmentaria/patología , Glucocorticoides/uso terapéutico , Humanos , Inmunosupresores/uso terapéutico , Lactante , Riñón/efectos de los fármacos , Riñón/patología , Masculino , Persona de Mediana Edad , Síndrome Nefrótico/tratamiento farmacológico , Síndrome Nefrótico/patología , Recurrencia , Inducción de Remisión , Estudios Retrospectivos , Resultado del Tratamiento , Adulto JovenRESUMEN
Mitochondrial neurogastrointestinal encephalomyopathy is a rare autosomal recessive disorder characterized by severe muscle wasting, gastrointestinal dysmotility, leukoencephalopathy, peripheral neuropathy, and ophthalmoplegia. The pathogenesis involves the accumulation of very high concentrations of nucleosides dThd and dUrd along with depletion of nucleotide dCTP. One of the treatment measures is the removal of nucleosides dThd and dUrd by hemodialysis and peritoneal dialysis. Only a few patient reports of dialysis as a measure to remove nucleosides had been reported.
Asunto(s)
Inmunosupresores/efectos adversos , Trasplante de Riñón/efectos adversos , Mycobacterium tuberculosis/patogenicidad , Infecciones Oportunistas/microbiología , Osteomielitis/microbiología , Tuberculosis Osteoarticular/microbiología , Adulto , Antituberculosos/uso terapéutico , Drenaje , Femenino , Humanos , Huésped Inmunocomprometido , Imagen por Resonancia Magnética , Mycobacterium tuberculosis/efectos de los fármacos , Mycobacterium tuberculosis/inmunología , Infecciones Oportunistas/diagnóstico , Infecciones Oportunistas/inmunología , Infecciones Oportunistas/terapia , Osteomielitis/diagnóstico , Osteomielitis/inmunología , Osteomielitis/terapia , Resultado del Tratamiento , Tuberculosis Osteoarticular/diagnóstico , Tuberculosis Osteoarticular/inmunología , Tuberculosis Osteoarticular/terapiaRESUMEN
Single dose (1 mg/rat) administration of VACOR (N-3-pyridyl methyl-N'-nitrophenyl urea) produced significant paralytic symptoms in rats. Such rats which lived for one week were sacrificed and serum AChE was extracted and purified by Sephadex column chromatography. The serum enzyme from the normal rats showed the existence of two isozymes on polyacrylamide gels which could be resolved through column chromatography. Both the isozymes showed non-competitive inhibition with VACOR in vitro; but to a varied degree. The ACh concentration increased by 70-75% in serum and 95-100% in erythrocytes of the poisoned rats. VACOR thus affects ACh hydrolysis thereby causing an accumulation of ACh in the serum of poisoned rats.