RESUMEN
Four cases of neuroendocrine carcinoma following Bowen's disease are presented. An immunohistochemical study was performed. The four patients, 3 men and a woman, ranging from seventy to eighty-seven years of age, developed a nodular tumor on a preexisting cutaneous lesion. In one of those cases the diagnosis of Bowen's disease was confirmed histologically before the apparition of the nodular tumor. The tumors were localized on the scalp, thorax, dorsum of the hand, and the scrotum. The four tumors were immunohistologically typical of neuro-endocrine carcinoma: there was a positivity for neurofilaments, cytokeratins and neurone-specific enolase. The clinico-pathological characteristics of those 4 neuro-endocrine carcinomas associated with a Bowen's disease, when compared with the 15 similar described in the literature, are identical to the isolated neuroendocrine carcinoma, from a clinical, morphological and evolutional point of view. The majority are seen in patients older than 60 years old and one third of the cases described survived at least 5 years. The coexistence of Bowen's disease and neuroendocrine carcinoma, the association of neuroendocrine and epidermoid cells in other cutaneous tumors, reactivate the controversy concerning the histogenesis of the so-called Merkel cell carcinoma. In fact, the histogenesis of the tumor is still not fully understood.
Asunto(s)
Enfermedad de Bowen/patología , Carcinoma de Células Escamosas/patología , Neoplasias Primarias Múltiples/patología , Neoplasias Cutáneas/patología , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Neoplasias Primarias Múltiples/análisis , Neoplasias Cutáneas/análisisRESUMEN
We report a case of lymphomatoid papulosis remarkable for its unusually early onset and spontaneous remission which has now lasted for 9 years.
Asunto(s)
Enfermedades de la Piel/patología , Piel/patología , Factores de Edad , Niño , Humanos , Lactante , Linfocitos/patología , Masculino , Remisión Espontánea , Factores de TiempoAsunto(s)
Cloaca/patología , Quistes/patología , Perineo/patología , Adulto , Quistes/cirugía , Humanos , Masculino , Metaplasia , Perineo/cirugíaAsunto(s)
Captopril/efectos adversos , Pénfigo/inducido químicamente , Prolina/análogos & derivados , Acantólisis/etiología , Acantólisis/patología , Captopril/uso terapéutico , Femenino , Humanos , Hipertensión/tratamiento farmacológico , Persona de Mediana Edad , Pénfigo/complicaciones , Piel/patologíaRESUMEN
A mixed infection induced by Microsporum canis and Trichophyton tonsurans has been observed on the scalp of a 10-year-old girl. Microscopy has shown microsporum-type endo-ectothrix parasitism on some hairs, whereas others exhibited a strictly trichophyton-type endothrix parasitism. This double parasitism was confirmed histologically (PAS coloration), and M. canis and T. tonsurans could be cultured. The infection was eradicated after 5 weeks of treatment with griseofulvin (750 mg/day per os) and local application of 1% Econazol spray solution twice a day.
Asunto(s)
Dermatomicosis/complicaciones , Dermatosis del Cuero Cabelludo/microbiología , Tiña/complicaciones , Niño , Dermatomicosis/microbiología , Femenino , Humanos , Microsporum/aislamiento & purificación , Tiña/microbiología , Trichophyton/aislamiento & purificaciónAsunto(s)
Micosis/terapia , Sinusitis/terapia , Senos Etmoidales , Femenino , Humanos , Masculino , Seno Maxilar , Micosis/diagnóstico , Sinusitis/microbiologíaAsunto(s)
Micosis/diagnóstico , Otitis Externa/etiología , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Micosis/terapia , Otitis Externa/terapiaRESUMEN
38 biopsies of perioral dermatitis have been examined. The following has consistently been observed: follicular hyperkeratosis; vasodilatation and oedema (sometimes very pronounced) of the papillary dermis; perivascular and parafollicular infiltrates consisting predominantly of lymphocytes, histiocytes and polymorphonuclear leucocytes. Occasionally, there have been epithelioid or giant cells, sarcoid-like infiltrates or vasculitis of the leucoclastic type. Demodex folliculorum was observed in only two sections and the follicles that contained them were not inflamed. This histological picture is very similar to that of acne rosacea.
Asunto(s)
Dermatitis/patología , Dermatosis Facial/patología , Adulto , Anciano , Edema/patología , Femenino , Cabello/patología , Humanos , Masculino , Persona de Mediana Edad , Piel/irrigación sanguínea , Piel/patología , VasodilataciónAsunto(s)
Antineoplásicos/uso terapéutico , Micosis Fungoide/terapia , Suero Antilinfocítico/uso terapéutico , Vacuna BCG/uso terapéutico , Bleomicina/uso terapéutico , Humanos , Leucaféresis , Mecloretamina/uso terapéutico , Micosis Fungoide/radioterapia , Compuestos de Nitrosourea/uso terapéutico , Factor de Transferencia/uso terapéuticoAsunto(s)
Mucormicosis/patología , Sinusitis/etiología , Econazol/uso terapéutico , Femenino , Humanos , Seno Maxilar/diagnóstico por imagen , Seno Maxilar/microbiología , Persona de Mediana Edad , Mucosa Bucal/patología , Radiografía , Rhizopus , Sinusitis/tratamiento farmacológico , Sinusitis/microbiología , Sinusitis/patología , Sinusitis/cirugíaRESUMEN
After a brief review of the characteristics of familial malignant melanoma, the authors summarize the literature about the BK mole syndrome. The clinical and histological features of this dermatosis are described. Three personal cases are also reported. The latter tend to demonstrate a certain genetic heterogeneity, while in the literature the BK mole syndrome has been described as an autosomal dominant trait.
Asunto(s)
Melanoma/genética , Neoplasias Cutáneas/genética , Adulto , Femenino , Genes Dominantes , Humanos , Masculino , Melanoma/patología , Persona de Mediana Edad , Neoplasias Cutáneas/patologíaRESUMEN
Since 1969, 79 cases of fungal maxillary sinusitis have been diagnosed. Forty-nine were due to Aspergillus fumigatus. There were no underlying diseases which depressed cellular immunity and no patient was receiving immunosuppressive drugs or corticosteroids. Most patients had received antibacterial therapy before the appearance of FMS. Treatment was by surgery, nystatin and econazole.