RESUMEN

Fanconi's anemia (FA) is a rare autosomal recessive syndrome associated with a strong predisposition to cancer, particularly squamous cell carcinoma (SCC) of various organs. A few cases of lower genital tract neoplasia have been described. We present a 14-year-old black girl with an advanced squamous cell vulvar carcinoma treated with cisplatin chemotherapy plus radiation therapy. The patient died because of fungal sepsis. Polymerase chain reaction (PCR) was positive to human papillomavirus (HPV)-16. Vulvar carcinoma is a very rare condition in teenagers, but the association of Fanconi's anemia and SCC of many sites is common. Vulvar carcinoma when associated with Fanconi's anemia is a great treatment challenge.

Asunto(s)

Carcinoma de Células Escamosas/etiología , Anemia de Fanconi/complicaciones , Neoplasias de la Vulva/etiología , Adolescente , Antineoplásicos/uso terapéutico , Candidiasis/complicaciones , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/terapia , Cisplatino/uso terapéutico , Terapia Combinada , Anemia de Fanconi/tratamiento farmacológico , Resultado Fatal , Femenino , Filgrastim , Factor Estimulante de Colonias de Granulocitos/uso terapéutico , Humanos , Infecciones Oportunistas/complicaciones , Proteínas Recombinantes , Neoplasias de la Vulva/complicaciones , Neoplasias de la Vulva/terapia