RESUMEN
HLA typing done in 10 Mexican mestizo patients with Behcet's syndrome revealed that 7 of them had HLA-B5 antigen as compared to a frequency of 31% in a Mexican mestizo control population. These findings are akin to those made in Japan and Turkey but differ from those made in Caucasian populations in the United States and Great Britain. Ethnic groups with a high frequency of HLA-B5 in Asia and America may belong to the same ancestral trunk. The occurrence of Behcet's syndrome in them may be more frequently HLA-B5 positive than in other ethnic groups.
Asunto(s)
Síndrome de Behçet/inmunología , Antígenos HLA , Síndrome de Behçet/epidemiología , Femenino , Humanos , Masculino , MéxicoAsunto(s)
Síndrome de Behçet/patología , Adolescente , Adulto , Síndrome de Behçet/inmunología , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Persona de Mediana Edad , Linfocitos T/patologíaRESUMEN
Se presenta el analisis clinico e inmunologico de doce pacientes con enfermedad de Behcet Este ocurrio con mayor frecuencia en la tercera decada de la vida. Los sintomas iniciales mas frecuentes fueron los de la triada clasica de ulceraciones orales, genitales e iritis. Caracteristicamente, las ulceras orales fueron resistentes al tratamiento. La lesion ocular mas frecuente fue la conjuntivitis, seguida por iridociclitis. El hipopion se observo solo en un paciente y el sindrome de Sjogren en dos. Siete pacientes tuvieron sintomas articulares. Hubo tromboflebitis en cuatro pacientes y embolias pulmonares en dos. Otras manifestaciones incluyeron: pericarditis, fibrosis pulmonar, epididimitis y manifestaciones del sistema nervioso central.Se observo disminucion del C3 y aumento de la IgG y la IgA en cinco de ochos pacientes. Hubo linfopenia T en cuatro pacientes con enfermedad activa. La linfopenia T, la asociacion con sindrome de Sjogren y el infiltrado inflamativo perivascular apoyan la participacion del sistema inmune en la patogenia de la enfermedad
Asunto(s)
Síndrome de BehçetRESUMEN
Eighty percent of 31 untreated patients with systemic lupus erythematosus (SLE) had abnormalities in their spontaneously expanded and/or Con-A-induced suppressor cell function, but the association of defects detected with both systems was only 68%. Loss of spontaneous suppression related positively to disease activity (r = 0.641) and the number of T gamma cells (r = 0.624) whereas Con-A-induced suppression correlated negatively with disease activity (r = -0.456) and the number of T gamma cells (r = 0.089). Incubation of mononuclear cells from SLE patients in antiribonucleoprotein IgG caused further loss of suppression in some, but not all, instances. The suppressor cell dysfunction found in SLE may result from diverse mechanisms, including a basic defect in the generation of suppressor cells and the abrogation of suppressor function by autoantibodies.