RESUMEN

Progressive supranuclear palsy (PSP) is a rare form of parkinsonism. The incidence rates are about 0.3-1.1 cases per 100,000 persons. The only two case-control studies performed up to now show conflictual results as regards education and residence in rural areas. Recently, a cluster of PSP and atypical parkinsonism has been observed in French Antilles. The hypothesis is that a consumption of both tropical fruit and herbal tea may be associated with PSP onset. Some PSP families with a probably autosomal dominant transmission have been described. A high frequency of a tau haplotype (H1/H1) associated with PSP is reported by some authors. The significance of this association is still not clear. We have performed a case-control study on 58 PSP cases, 116 hospital controls and 58 population controls.

Asunto(s)

Parálisis Supranuclear Progresiva/epidemiología , Edad de Inicio , Bebidas/efectos adversos , Exposición a Riesgos Ambientales , Femenino , Pruebas Genéticas , Guadalupe/epidemiología , Humanos , Incidencia , Masculino , Mutación/genética , Enfermedades Profesionales/epidemiología , Prevalencia , Factores de Riesgo , Factores Sexuales , Parálisis Supranuclear Progresiva/fisiopatología , Proteínas tau/genética