RESUMEN
We report a retrospective study of 64 patients with primary squamous cell carcinoma of the oropharynx. The tumours were classified by the UICC (Union Internationale Contre le Cancer) system and a New Tumour Staging (NTS) system. Results showed a crude survival of 29% at 5 years. The most important prognostic factor for survival rate was the tumour (T) stage in both classifications. NTS recommendations that consider the number of sites and subsites involved yield a better correlation between survival and T stage. NTS also discriminates better between the T stages than the UICC criteria.
Asunto(s)
Carcinoma de Células Escamosas/patología , Neoplasias Orofaríngeas/patología , Adulto , Anciano , Anciano de 80 o más Años , Análisis de Varianza , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Carcinoma de Células Escamosas/diagnóstico por imagen , Carcinoma de Células Escamosas/tratamiento farmacológico , Carcinoma de Células Escamosas/cirugía , Intervalos de Confianza , Femenino , Estudios de Seguimiento , Humanos , Escisión del Ganglio Linfático , Masculino , Persona de Mediana Edad , Análisis Multivariante , Invasividad Neoplásica , Estadificación de Neoplasias , Neoplasias Orofaríngeas/tratamiento farmacológico , Neoplasias Orofaríngeas/radioterapia , Neoplasias Orofaríngeas/cirugía , Pronóstico , Modelos de Riesgos Proporcionales , Radiografía , Dosificación Radioterapéutica , Radioterapia Adyuvante , Estudios Retrospectivos , Tasa de SupervivenciaRESUMEN
The incidence of local recurrence of colo-rectal carcinoma is about 15-50%. The parietal recurrence is localized next parietal incision and its incidence is rare (0.2-2%). The treatment of this lesion is based on palliative radiotherapy and chemotherapy; the surgical treatment is based on parietal resection. The Authors describe a case of parietal recurrence after colo-rectal adenocarcinoma and conclude that the prognosis of this lesions is infaust.
Asunto(s)
Adenocarcinoma/cirugía , Neoplasias Colorrectales/cirugía , Recurrencia Local de Neoplasia , Adenocarcinoma/mortalidad , Anciano , Neoplasias Colorrectales/mortalidad , Femenino , Humanos , Recurrencia Local de Neoplasia/mortalidad , Cuidados Paliativos , PronósticoRESUMEN
The role of some so-called primary and secondary (or oligo-elements) elements in the physiopathology of the cardiocirculatory system has been well known from a number of years and they have been regularly included in the treatment protocols. Some, including K, Ca, Mg and Zn, are extremely well known and widely used in clinical practice. Recently, however, a growing number of studies have focused on the biological importance of other oligo-elements in the pathogenetic mechanisms of atherogenesis and its clinical manifestations. This study aimed to verify the exact role of free cobalt in the physiopathology of the chronic obstructive arterial diseases (COAD). A total of 80 patients affected by 2nd stage COAD were examined and the levels of some oligo-elements, including Co, were assayed. Constantly low levels were found (85% of cases) in relation to other oligo-elements studied (Cu, Zn, Mg, Ca). This findings is particularly interesting since it confirms the biochemical hypothesis of atherosclerosis according to which parietal damage plays a central role in the pathogenetic mechanism. Some enzymatic deficiencies, which lead to changes in membrane stability at the level of the endothelial cells, are closely related to the presence of tissutal and humoral peroxidation products. These peroxides (lipid peroxides), which are formed following the interaction of fatty acids with oxygen free radicals, have been identified by a number of studies as being responsible for endothelial damage. Several authors have shown that lipid peroxidation is involved in the atherogenic process through several mechanisms entailing monocytic activity and reduced prostacyclin (PG2) synthesis.(ABSTRACT TRUNCATED AT 250 WORDS)
Asunto(s)
Arteriopatías Oclusivas/tratamiento farmacológico , Arteriosclerosis/tratamiento farmacológico , Cobalto/deficiencia , Arteriopatías Oclusivas/sangre , Arteriopatías Oclusivas/fisiopatología , Arteriosclerosis/sangre , Arteriosclerosis/fisiopatología , Enfermedad Crónica , Cobalto/sangre , Cobalto/uso terapéutico , Femenino , Humanos , Masculino , Oligoelementos/sangreRESUMEN
The heterogeneity of the buffalo k-casein, treated with 2-mercaptoethanol, has been estimated by disk gel-polyacrylamide electrophoresis on 428 caseins isolated from individual milks. The investigation showed six electrophoretic fractions: A, B, C, D, E, F, that, in ten buffalo farms considered formed ten different groups: ABCDEF; ABCDE; ABCEF; ABCE; BCDE; CDEF; BCE; CDE; CEF; and CE. The group ABCDE is the only that is present in all ten farms considered and presents on the whole, the greater number of observations (161). The fraction C is the most abundant. The investigation showed the heterogeneity of the gamma fraction, showing five electrophoretic fractions: A, B, C, D, E, that constitute the nine following groups; ABCDE; ABCD; BCDE; ABD; BCD; ABC; BD; BC and AB. At present a possible correlation to genetic factors seems hazardous.