RESUMEN

The efficacy of a new fenbendazile formulation produced by nanotechnology-based drug delivery system was investigated in45 sheep naturally infected with gastrointestinal nematodes. The formulation showed 95.6% efficacy against Nematodes spp. at a dose of 1.0 mg/kg dw of its active ingredient and 100% efficacy against other species of gastrointestinal nematodes. Given at a dose of 10 mg/kg dw, the basic drug--fenbendazole (substance) displayed 96.39 and 100% efficacy, respectively.

Asunto(s)

Sistemas de Liberación de Medicamentos , Fenbendazol/administración & dosificación , Infecciones por Nematodos/tratamiento farmacológico , Enfermedades de las Ovejas/tratamiento farmacológico , Animales , Nanotecnología , Nematodos/efectos de los fármacos , Nematodos/parasitología , Infecciones por Nematodos/parasitología , Ovinos , Enfermedades de las Ovejas/parasitología