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Genet Mol Res ; 14(2): 6251-5, 2015 Jun 11.
Artículo en Inglés | MEDLINE | ID: mdl-26125826

RESUMEN

We investigated the antioxidant content and conducted a cytological examination of the aqueous fluid and lenses of patients with age-related cataracts at different stages. The levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX) in the aqueous fluid and lenses were determined by the xanthine oxidase method, the colorimetric method, and the improved reduced glutathione (GSH) depletion method, respectively. SOD, CAT, and GSH-PX content in the aqueous fluid and lenses decreased significantly with increasing lenticular nucleus hardness grading. However, the number of white blood cells, neutrophils, monocytes, lymphocytes, and eosinophils did not vary significantly with varying lenticular nucleus hardness. Antioxidant content examination is an important quantitative indicator for clinical diagnosis and treatment of age-related cataracts. Antioxidant content in the aqueous fluid and lenses decreased significantly with increasing lenticular nucleus hardness grading. Lenses at hardness level V had the lowest content of antioxidants.


Asunto(s)
Humor Acuoso/enzimología , Catalasa/biosíntesis , Catarata/genética , Glutatión Peroxidasa/biosíntesis , Superóxido Dismutasa/biosíntesis , Factores de Edad , Anciano , Anciano de 80 o más Años , Antioxidantes/metabolismo , Humor Acuoso/metabolismo , Catalasa/metabolismo , Catarata/metabolismo , Catarata/patología , Femenino , Glutatión/biosíntesis , Glutatión/metabolismo , Glutatión Peroxidasa/metabolismo , Humanos , Masculino , Persona de Mediana Edad , Superóxido Dismutasa/metabolismo
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