1.
Angew Chem Int Ed Engl
; 57(38): 12328-12332, 2018 09 17.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30074668
RESUMEN
Sterically hindered substrates can be employed in an enantioselective palladium-catalyzed α-arylation with the chiral monophosphorus ligand BI-DIME. This process enabled an efficient synthesis of the antidepressant (S)-nafenodone, a four-step enantioselective synthesis of the Sceletium alkaloid (+)-sceletiumâ A-4, a concise five-step enantioselective synthesis of (-)-corynoline, as well as a three-step preparation of (-)-DeN-corynoline.