Asunto(s)
Preparaciones Farmacéuticas/análisis , Trastornos Relacionados con Sustancias/diagnóstico , Austria , Barbitúricos/envenenamiento , Antagonistas de los Receptores Histamínicos H1/envenenamiento , Humanos , Trastornos Relacionados con Sustancias/sangre , Trastornos Relacionados con Sustancias/orinaAsunto(s)
Catálogos de Medicamentos como Asunto , Quimioterapia , Medicina Legal , Austria , HumanosRESUMEN
A new lubricant containing diphenhydramine hydrochloride has been recently introduced for catheterization procedures. Absorption of the active agent through the urethra was assessed by means of blood sample determinations. The results were compared with the already-known values after oral intake and were very low. The maximum concentration was 0.4 microgram.
Asunto(s)
Difenhidramina/metabolismo , Uretra/fisiología , Absorción , Difenhidramina/sangre , Humanos , MasculinoRESUMEN
A procedure for fast screening of urine sample is described. TLC and GC equipped with NPD enable detection of therapeutic doses of drugs to be made in a short time. Tables of retention values for TLC and GC are also presented. TLC detects drugs with a sequence of three reagents. GC screening is carried out with a temperature programmed run of 30 degrees C/min up to 290 degreesC. For the determination of retention indices new polar phases with suitable thermal stabilities such as OV-225 and OV-275 are used.