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Comparative analysis of the treatment results in 120 patients, suffering destructive form of biliary calculous disease (DFBCD) was performed. Depending on operative access and postoperative conservative therapy applied the patients were divided into two groups. In the main group in 58 patients, suffering DFBCD, a minilaparotomy access was applied, using "mini-assistant" apparatus named after M. I. Prudkov and postoperatively--low-intensive laser irradiation and regional lymphotropic therapy. In a comparison group in 62 patients various laparotomic accesses were used, and a standard postoperative therapy was performed. Normalization of clinical, laboratory and immune indices in the main group were observed in twice earlier than in a control one, and economical together with moral-psychological effect was measured in reduction of the medicines quantity used as well as the patients stationary stay.

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The study is based on the examination of 12 patients with perforative duodenal ulcer and 24 patients operated on recurrent bleeding duodenal ulcer. Some component of the immune system, such as T- and B-lymphocytes rates, immunoglobulin rate and macrophagal activity, were decreased prior the beginning of the complex treatment. Normalisation of humoral and cell immunity was registered on 10-12 days after the beginning of the ozone and low-intensive laser irradiation.

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An analysis of results of treatment of 85 patients subjected to planned operations for calculous cholecystitis and inguinal hernias with the application of high-energy CO2 and YAG laser, surgical scalpel was performed. For local treatment of the aseptic wounds radiation of semiconduction arsenide gallium laser "Uzor" was used. Results of the investigation suggest that laser infrared radiation promotes rapid liquidation of acute inflammatory symptoms, quicker healing and smooth course of the postoperative period. The method is recommended for wide introduction into clinical practice.

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In the experiment on 218 white rats, it was established that preliminary influencing upon the site of a future incision with the infrared laser radiation in constant regime within the range of from 1 to 150 mW (dosage of radiation per 1 field of 0.06-9.3 J/cm2) facilitated pronounced stimulation of the processes of collagen formation and significant increase in strength of a forming scar. In increasing the power of radiation, the reparative processes in a wound are slowed and disturbed; in power of 250 mW, a wound heals by second intention, in average, after (32.6 +/- 3.2) days.

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The article analyses the results of treatment of 150 patients with purulent diseases of the soft tissues of various localization, in which after surgical treatment the purulent focus immobilized trypsin (50 patients), trypsin with lysozyme immobilized on gauze (50 patients), and antiseptics (50 patients) were used for topical treatment of the formed wounds. The results of the treatment showed that topical prolonged enzyme therapy of purulent wounds with the use of trypsin immobilized on gauze and that with lysozyme promotes cleansing of the wounds, reduces microbial dissemination, intensifies reparative processes, and reduces the terms of treatment.

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The results of treatment of 370 patients with purulent soft tissue diseases have shown that laseroenzymotherapy of the suppurating wounds contributed to their rapid cleaning, maintenance of microbial colonization at a stable low level, activation of reparative processes. This permitted to prepare a wound surface for closure at the nearest days after the operation.

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The results of treatment of 245 patients with purulent diseases of the soft tissues are discussed. The course of the wound process was most favourable with the use of immobilized trypsin on gauze in the management of wounds formed after surgical debridement of purulent foci by means of CO2 laser. The method made it possible to accelerate the processes of necrolysis, provide a stable low level of dissemination of bacteria in the wound tissues, reduce the term of preparation of the wound for the application of secondary sutures and the terms of healing.

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The results of ++clinico-bacterial examination of 168 patients provide evidence for the efficacy of CO2-laser treatment of a purulent wound; it reduces contamination of the tissues, 1,000-10,000-fold as a result of which surgical debridement of the purulent wound is completed in most cases by the application of a primary suture. The use of immobilized proteolytic enzymes in the postoperative period facilitates further cleansing of the wound, prevents the development of secondary infection, accelerates the change of the wound process to the phase of regeneration, promotes an uneventful postoperative course and healing of the wound within a lesser period as compared to the control group.

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