RESUMEN
Objective To probe the feasibility of the aneurysm embolization with fibrin glue-fibroblast compound by carotid artery angiography and pathological examination in New Zealand rabbit model. Methods The primarily cultured fibroblast cells were obtained by tissue engineering technique in vitro, and the fibroblast bank was established. Then fibroblast cells were cultured in human fibrin glue. Aneurysms of 12 rabbits were embolized directly by fibrin glue-fibroblast compound in 6 cases or fibrin glue in the other 6 cases. DSA angiography was performed 2 and 4 weeks after embolization, and pathological examination was conducted 4 weeks after embolization. Results Fibroblasts grew in fibrin glue in vitro. Embolization efficacy of fibrin glue-fibroblast compound was obviously superior to that of fibrin glue only. Conclusions Fibrin glue-fibroblast compound can be considered as candidate material for aneurysm embolization.