RESUMEN
Rapid, accurate and inexpensive methods are essential to detect drug-resistant Mycobacterium tuberculosis and allow timely application of effective treatment and precautions to prevent transmission. The proportion method, the MTT and Alamar Blue redox methods, and the D29 mycobacteriophage assay, were compared for their ability to detect resistance to isoniazid and rifampicin. When tested against a panel of known M. tuberculosis strains, the redox methods and the D29 assay showed good sensitivity and specificity compared to the proportion method, suggesting that they could be useful alternatives for identifying multidrug resistance in M. tuberculosis.
Asunto(s)
Antituberculosos/farmacología , Isoniazida/farmacología , Pruebas de Sensibilidad Microbiana/métodos , Mycobacterium tuberculosis/efectos de los fármacos , Rifampin/farmacología , Costos y Análisis de Costo , Farmacorresistencia Bacteriana , Pruebas de Sensibilidad Microbiana/economía , Micobacteriófagos/aislamiento & purificación , Micobacteriófagos/fisiología , Oxazinas , Oxidación-Reducción , Sensibilidad y Especificidad , Sales de Tetrazolio , Tiazoles , XantenosAsunto(s)
Disgenesia Gonadal 46 XY/patología , Hernia Inguinal/patología , Cromosoma Y , Adulto , Criptorquidismo , Humanos , Masculino , FenotipoRESUMEN
PIP: Reasons for IUD removal are described in a study carried out in Santa Maria, Brazil. 148 IUD users were studied. The principal reason for removal was excessive bleeding, principally related to the Lippes Loop IUD. 50% of the patients were between 40 and 45 years of age; 30.8% between 15 and 19. 4.7% of the removals were due to pelvic complications and among them, 9.3% were using Lippes Loop, and only 0.8% the Copper T. The following were concluded: IUD is a contraceptive method with an acceptable number of complications; The Lippes Loop IUD provoked excessive bleeding, being the main reason for removal; the acute pelvic inflammation could be treated with the IUD in situ; dysmenorrhea was not a significant reason for removal; the Copper T device proved to be less prone to complications.^ieng