RESUMEN
AIMS: Neonatal septicemia may have a mortality of 20% in newborns small for their-gestational age. This susceptibility for infections has been explained by immunological disorders. The aim of this study to know the effect of levamisole on the functions of chemotaxis and bacterial activity of PMN cells in newborns small for their-gestational age. MATERIAL AND METHODS: Twenty full-term newborns were studied. Ten of them were small for their-gestational age, and the other 10 had body weight within the normal range. Microbicidal activity and chemotaxis were measured, and comparisons between groups were made with non-parametric statistical tests. RESULTS: In the group of newborns small for their-gestational age. Microbicidal activity was similar to control group, but chemotactic activity was reduced (p < 0.05).
Asunto(s)
Recién Nacido Pequeño para la Edad Gestacional/inmunología , Levamisol/farmacología , Neutrófilos/efectos de los fármacos , Neutrófilos/fisiología , Actividad Bactericida de la Sangre , Quimiotaxis de Leucocito/efectos de los fármacos , Femenino , Humanos , Recién Nacido , MasculinoRESUMEN
The aim of this study is to demonstrate the transference of PPD hypersensibility in an in vitro model, with dialysable colostral leukocyte extract (DCLE) of PPD+ and PPD-mothers, through measurements of leukocyte migration inhibition factor activity (LIF) from blood obtained of the umbilical cord of newborns from PPD+ mothers. The results show that DCLE PPD+ incubated with leukocytes of newborns from PPD- mothers had inhibition of leukocyte migration compared with migration of leukocytes incubated with DCLE PPD-. These results suggest that in this in vitro model, DCLE transfers hypersensibility to PPD.