RESUMEN
Iron-deficiency anemia occurs in 3.5 to 5.3% of adult men and postmenopausal women. Occult gastrointestinal bleeding is the cause in the vast majority of cases. After endoscopic examinations have ruled out lesions in colon and upper gastrointestinal tract, 5 to 20% of those patients remain without diagnosis. Angiodysplasias and tumors are the most common causes of occult bleeding arising from the small bowel. Their diagnosis requires complex studies with quite low yield. However, it is necessary to perform them when anemia becomes severe or persistent. We report the case of a male patient with severe and persistent iron-deficiency anemia who had a stromal gastrointestinal tumor located in the ileum.
Asunto(s)
Anemia Ferropénica/etiología , Hemorragia Gastrointestinal/complicaciones , Neoplasias del Íleon/complicaciones , Angiodisplasia/complicaciones , Humanos , Neoplasias del Íleon/patología , Masculino , Persona de Mediana EdadRESUMEN
La anemia ferropénica ocurre en el 3,5% al 5,3% de los varones adultos y de las mujeres menopáusicas. La pérdida digestiva crónica es la causa en la mayoría de los casos. Cinco a 20% de los pacientes quedan sin diagnóstico tras haberse descartado por estudios endoscópicos lesiones en el colon y en el tracto digestivo superior. En el intestino delgado, las angiodisplasias y los tumores son las causas más frecuentes de sangrado intestinal oculto. Su diagnóstico requiere la realización de estudios complejos con bajo rendimiento que necesariamente hay que instrumentar en los casos anemia ferropénica.
Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Anemia Ferropénica/etiología , Hemorragia Gastrointestinal/complicaciones , Neoplasias del Íleon/complicaciones , Angiodisplasia/complicaciones , Neoplasias del Íleon/patologíaRESUMEN
Pure red cell aplasia developed in a female patient with systemic lupus erythematosus (SLE). Erythroid colony growth was assessed in semisolid medium culture of bone marrow obtained from a normal donor and cultured in the presence of normal and patient sera. Colony forming units of erythropoiesis and burst forming units of erythropoiesis obtained from a normal donor were inhibited in the presence of patient sera. Our findings support the concept that circulating inhibitors might influence the proliferation of erythroid progenitor cells and erythroid aplasia may be an immunologically mediated syndrome.