RESUMEN
The authors describe a pooled analysis of 23 French patients presenting with oral metastasis between 1981 and 2008. The reviewed cases were collected from the medical records of two cancer institutes. The inclusion criteria were: the histology of the metastases must be known; the primary location must be known; metastasis and primary location must be physically separated; and oral primary locations were excluded. This sample represent 0.48% of all oral malignancies treated during the period. The sex-ratio was 2.3:1 in favour of men, the mean age was 64.5 years (±13.2). Lungs and kidneys represent 52.2% of the primary cancer locations. In most cases, the primary cancer was a carcinoma or an adenocarcinoma (82.6%). The most affected oral regions were the gingiva and alveolar mucosa (60.7%), followed by the tongue (17.9%). The mean survival was 16.6 months. This sample is characterized by the relative absence of specific symptoms and quite different distribution in primary sites. Even if oral metastases are rare, their semiological value necessitates the histopathological examination of any oral tumour, and a systematic search in all patients with cancer history.
Asunto(s)
Mucosa Bucal/patología , Neoplasias de la Boca/secundario , Adenocarcinoma/secundario , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma/secundario , Femenino , Francia , Humanos , Neoplasias Maxilomandibulares/patología , Neoplasias Maxilomandibulares/secundario , Neoplasias Maxilomandibulares/terapia , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/patología , Neoplasias de la Boca/terapia , Estudios Retrospectivos , Sarcoma/secundario , Tasa de SupervivenciaRESUMEN
The mandible is a complex osteological structure composed of distinct units integrated into a single bone around the director axis of the mandibular nerve. In this study of the mandibular development, we use a method that synthesizes the contributions of each sub-unit, using the mandibular canal as reference system. This novel approach results in new informations and confirms the leading role of the mandibular nerve and of its curve in mandibular development. It would seem to be possible to explain a major part of mandibular development by the role of the nerve as guide.