RESUMEN

Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism. A prospective evaluation of 5 patients with Wilson's disease taking and not taking D-penicillamine for as long as 9.5 years showed subclinical hypothyroidism. D-penicillamine probably inhibited thyroperoxidase activity in utero in healthy infants and during childhood in patients with Wilson's disease.

Asunto(s)

Quelantes/efectos adversos , Quelantes/uso terapéutico , Bocio/inducido químicamente , Degeneración Hepatolenticular/tratamiento farmacológico , Hipotiroidismo/inducido químicamente , Penicilamina/efectos adversos , Penicilamina/uso terapéutico , Adolescente , Niño , Femenino , Bocio/tratamiento farmacológico , Humanos , Hipotiroidismo/tratamiento farmacológico , Recién Nacido , Masculino , Intercambio Materno-Fetal , Embarazo , Tirotropina/sangre , Tiroxina/uso terapéutico