RESUMEN
The importance of sugars to protein function is real and is of significant clinical relevance. Technology advances enable large population studies to be carried out, shedding light on individual sugar variation and variations with time. Three-dimensional mass spectroscopy on solid pathological specimens is going to open up a whole new world of pathology visualisation. The door is now open to exploit carbohydrate recognition in new therapeutics by identifying novel biomarkers in cancer to aid diagnosis, and also providing therapeutic targets for treatment. Glycan age correlates with biological age. This means we can map the reversal of biological age with exercise and diet.
Asunto(s)
Alergia e Inmunología , Glicómica , Polisacáridos/metabolismo , Proteínas/metabolismo , Azúcares/metabolismo , Glicosilación , Humanos , Neoplasias/diagnóstico , Neoplasias/metabolismo , Neoplasias/terapiaRESUMEN
Dosimeters were irradiated using the protocol described in the new ANSI HPS N13.11-2001 standard, "American National Standard for Dosimetry--Personnel Dosimetry Performance--Criteria for Testing." In particular, the following hypotheses were evaluated: (1) expanding the scope of testing fields in the x-ray category would not adversely impact the performance of dosimeter systems; (2) incorporating routine angular testing for medium-energy and high-energy photon fields would not adversely impact the performance of dosimeter systems; (3) implementing test criteria would adversely impact the performance of dosimeter systems; and (4) the narrow spectrum x-ray fields specified in the standard would provide adequate replacements for analogous k-fluorescence techniques previously used by DOELAP. The study tested only subcategories IIA, General photon fields, and IID, Plutonium-specific fields, and did not address mixed irradiations. The results of the study supported hypotheses (1) and (2) above. The results of the study indicated that the individual dosimeter performance test (10% rule) did not seriously impact the performance of dosimeter systems nor did results support the use of NS20 as a replacement x-ray field for the 17 keV k-fluorescence x-ray field.