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1.
Am J Vet Res ; 37(6): 631-4, 1976 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-937784

RESUMEN

The immunity of Holstein-Friesian dairy cows vaccinated against Coxiella burnetii was challenged with 4 X 10(8) infective guinea pig doses of viable rickettsiae. Cows that were vaccinated had normal full-term calves, whereas 2 nonvaccinated cows aborted late in pregnancy. Intrauterine infection of the fetus was indicated by recovery of the organism from tissues of the fetus. Coxiella burnetii was recovered from milk, colostrum, and placenta of vaccinated and nonvaccinated cows after challenge inoculation, but the rickettsiae recovered were as many as 1,000 times more numerous in nonvacinated cows.


Asunto(s)
Enfermedades de los Bovinos/inmunología , Coxiella/inmunología , Fiebre Q/veterinaria , Vacunación/veterinaria , Aborto Veterinario/microbiología , Animales , Anticuerpos Antibacterianos/análisis , Bovinos , Enfermedades de los Bovinos/microbiología , Calostro/inmunología , Calostro/microbiología , Coxiella/aislamiento & purificación , Femenino , Feto/microbiología , Inmunoglobulina G/análisis , Inmunoglobulina M/análisis , Ratones , Leche/microbiología , Embarazo , Fiebre Q/inmunología , Fiebre Q/microbiología
2.
Am J Vet Res ; 37(4): 389-94, 1976 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-773223

RESUMEN

Bactericidal activity for a serum-sensitive Aerobacter aerogenes strain was associated with antibodies present in immunoglobulin G1 (IgG1) and immunoglobulin M (IgM), with the greatest activity on a weight basis in IgM. Activity in immunoglobulin G2 was absent. A total of 118 serums were prepared from blood collected from neonatal calves on farms experiencing unusually high mortality from diarrhea. The serums were allotted to 4 groups on the basis of total serum protein concentrations as follows: group I=7.0 to 9.5 g/dl, group II=6.00 to 6.98 g/dl, group III=5.00 to 5.90 g/dl, and group IV=3.9 to 4.9 g/dl. Bactericidal activity for the serum-sensitive aerobacter strain was distributed approximately equally throughout the 4 groups. Activity for 3 strains of Escherichia coli was minimal to absent. Concentrations of IgG1 and IgM were determined in 82 of the serums. Concentrations of IgG1 ranged from 0 to 54.2 mg/ml, with overlapping among the 4 groups. Concentrations of IgM could not be determined in serums with concentrations greater than 1.6 mg/ml. However, bactericidal activity did not correlate with the immunoglobulin concentrations, since activity was present to the same degree in serums with small concentrations of immunoglobulins compared with serums with as much as threefold larger concentrations.


Asunto(s)
Animales Recién Nacidos/inmunología , Actividad Bactericida de la Sangre , Proteínas Sanguíneas/análisis , Bovinos/inmunología , Escherichia coli/inmunología , Inmunoglobulina G/análisis , Inmunoglobulina M/análisis , Animales , Enterobacter/inmunología , Técnicas In Vitro
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