1.
Neurology
; 36(3): 357-61, 1986 Mar.
Artículo
en Inglés
| MEDLINE
| ID: mdl-3951702
RESUMEN
Monounsaturated fatty acids, especially oleic acid (C18:1), decreased the content of saturated very-long-chain fatty acids (VLFA) in cultured skin fibroblasts from patients with adrenoleukodystrophy (ALD) and controls. When confluent ALD fibroblasts were incubated with oleic acid for 5 days in lipid-free medium, which eliminates uptake of exogenous VLFA, the mean cell content of C26:0 was decreased by 33.7 +/- 10.1%. Oleic acid inhibited C26:0 synthesis in ALD fibroblasts by 58% and total fatty acid synthesis by 68 to 78%. Therefore, the elevated C26:0 levels in ALD cells may be lowered by inhibiting fatty acid biosynthesis, and inhibition of saturated VLFA synthesis by oleate may be useful in treating ALD.
Asunto(s)
Adrenoleucodistrofia/metabolismo , Esclerosis Cerebral Difusa de Schilder/metabolismo , Ácidos Grasos/metabolismo , Fibroblastos/metabolismo , Ácidos Oléicos/farmacología , Animales , Bovinos , Línea Celular , Femenino , Humanos , Técnicas In Vitro , Masculino , Ácido Oléico , Piel/metabolismo
2.
Pediatrics
; 68(5): 751-2, 1981 Nov.
Artículo
en Inglés
| MEDLINE
| ID: mdl-7312485