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PURPOSE: To evaluate the long-term cognitive function in children treated with intravitreal ranibizumab (IVR) for retinopathy of prematurity(ROP), and the impact of IVR on the growth and ocular development. METHODS: In this retrospective study, the premature children aged 4 to 9 years who received monotherapy of IVR (IVR group, n = 25) or monotherapy of laser photocoagulation (LP) (LP group, n = 33) for ROP, and the same age premature children with no ROP (Control group, n = 26) were enrolled from 2020 to 2022 in the pediatric fundus clinic of Shenzhen Eye Hospital. Main outcome measures were full-scale intelligence quotient (FSIQ) and index score using the Chinese version of the Wechsler intelligence scale for children-fourth edition (WISC-IV) and Wechsler preschool and primary scale of intelligence-fourth edition (WPPSI-IV). All children were examined and analyzed for growth and ocular development by recording the height, weight, head circumference, spherical equivalent (SE), best corrected visual acuity (BCVA) and axial length (AL). RESULTS: There were 17 children in IVR group, 17 in LP group, and 11 in Control group who received the WISC-IV assessment. There were no significant differences in FSIQ, verbal comprehension index, perceptual reasoning index, working memory index, processing speed index, general ability index and cognitive efficiency index among the three groups. There were 8 children in IVR group, 16 in LP group, and 15 in Control group who received the WPPSI-IV assessment. There were no significant differences in FSIQ, verbal comprehension index, visuospatial index, fluid reasoning index, working memory index, non-verbal index, general ability index and cognitive efficiency index among the three groups. There was no significant difference in BCVA among the three groups (P = 0.74), however, there is an increase for AL in IVR group when compared with LP group (22.60 ± 0.58 vs. 22.13 ± 0.84, P = 0.003), and the ROP patients of IVR group have a significant increase in the AL compared to the Control group(22.60 ± 0.58 vs. 22.03 ± 0.71, P < 0.0001). CONCLUSIONS: Children with a history of IVR have a similar cognitive function outcomes compared to those with a history of LP or were premature without ROP. ROP children with a history of IVR has longer AL than those treated with LP.

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Diabetic retinopathy (DR) is the leading etiology of blindness in the working population of the USA. Its long-term management relies on effective glycemic control. Seven anti-diabetic classes have been introduced for patients with type 2 diabetes (T2D) in the past two decades, with different glucose-lowering and cardiovascular benefits. Yet, their effects specifically on DR have not been studied in detail. A systematic review of the literature was conducted to investigate this topic, focusing on the available clinical data for T2D. Published studies were evaluated based on their level of statistical evidence, as long as they incorporated at least one endpoint or adverse event pertaining to retinal health. Fifty nine articles met our inclusion criteria and were grouped per anti-diabetic class as follows: alpha-glucosidase inhibitors (1), peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists (8), amylin analogs (1), glucagon-like peptide-1 (GLP-1) receptor agonists (28), dipeptidyl peptidase 4 (DPP-4) inhibitors (9), and sodium glucose co-transporter-2 (SGLT-2) inhibitors (9), plus one retrospective study and two meta-analyses evaluating more than one of the aforementioned anti-diabetic categories. We also reviewed publicly-announced results of trials for the recently-introduced class of twincretins. The available data indicates that most drugs in the newer anti-diabetic classes are neutral to DR progression; however, there are subclasses differences in specific drugs and T2D populations. In particular, there is evidence suggesting there may be worse diabetic macular edema with PPAR-gamma agonists, potential slight DR worsening with semaglutide (GLP-1 receptor agonist), and potential slight increase in the incidence of retinal vein occlusion in elderly and patients with advanced kidney disease receiving SGLT-2 inhibitors. All these warrant further investigation. Longer follow-up and systematic assessment of at least one DR-related endpoint are highly recommended for all future trials in the T2D field, to ultimately address this topic.

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Resumo Introdução O adoecimento pode ser um fator limitante para a realização das ocupações, principalmente quando se está internado em uma Unidade de Terapia Intensiva (UTI). O ambiente da UTI, que está associado à rotina rígida e procedimentos invasivos, pode trazer diferentes repercussões à pessoa internada. Nesta pesquisa, considerou-se a visão sobre a pessoa com base na Logoterapia e Análise Existencial de Viktor Frankl, que compreende o ser humano em sua totalidade e como capaz de suportar o sofrimento e encontrar o sentido da vida por meio da realização de valores. Objetivo Compreender como se apresentam as ocupações para a pessoa internada em uma UTI Coronariana e abordá-las considerando a liberdade e os valores. Método Pesquisa qualitativa, exploratória, descritiva, do tipo estudo de caso. Os dados foram coletados por meio de uma entrevista semiestruturada e uma atividade de expressão livre. Resultados Observou-se que a rotina da UTI impacta as ocupações, assim como a ocorrência de perda da autonomia e independência e a manifestação de sentimentos de medo, ansiedade e isolamento social. Apesar disso, considerando a liberdade do ser humano que remete a dimensão noética, a participante se posicionou mediante as dificuldades realizando valores criativos, vivenciais e atitudinais. Conclusão A forma como a internação em UTI impacta as ocupações pode ser modificada se a pessoa assumir uma atitude alternativa diante das condições dadas. Nesse contexto, o envolvimento em ocupações pode possibilitar a realização de valores, o que favorece o encontro de um novo sentido da vida.

Abstract Introduction Illness can be a limiting factor for engaging in occupations, especially when the person hospitalized in an Intensive Care Unit (ICU). The ICU environment, which is associated with a rigid routine and invasive procedures, can have various repercussions for the hospitalized individual. In this study, the perspective on the individual is based on Viktor Frankl's Logotherapy and Existential Analysis, which views humans in their entirety and as capable of enduring suffering and finding meaning in life through the realization of values. Objective Understand how occupations are experienced by individuals in a Coronary ICU and address them considering freedom and values. Method This is a qualitative, exploratory, descriptive case study. Data were collected through a semi-structured interview and a free expression activity. Results It was observed that the ICU routine impacts occupations, as does the loss of autonomy and independence and the manifestation of feelings of fear, anxiety, and social isolation. Nevertheless, considering the human dimension of noetic freedom, the participant responded to these challenges by realizing creative, experiential, and attitudinal values. Conclusion The way hospitalization in an ICU impacts occupations can be modified if the individual adopts an alternative attitude towards the given conditions. In this context, engaging in occupations can enable the realization of values, which facilitates finding a new meaning of life.

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Resumo Introdução A doença de Parkinson (DP) é a segunda no grupo das doenças neurodegenerativas crônicas progressivas, com alta prevalência e incidência anual. Portanto, faz-se necessário atualizar as opções terapêutico-ocupacionais, vigentes ou em desenvolvimento, para essa patologia. Objetivo Mapear as práticas e abordagens de terapeutas ocupacionais conduzidas por meio de intervenções terapêuticas na DP. Método Revisão conduzida em atenção ao "Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist", baseada na metodologia do Joanna Briggs Institute. A pergunta de pesquisa foi elaborada a partir do acrônimo PCC (Paciente, Conceito e Contexto), cujos termos principais e secundários foram consultados no DeCS/MeSH. As buscas foram realizadas em cinco plataformas científicas entre 2011 e 2020. Os pesquisadores cegos foram comparados pelo grau de concordância aferido pelo coeficiente kappa de Cohen. Resultados Os achados indicam que há pelo menos oito categorias de práticas e abordagens realizadas por terapeutas ocupacionais na DP. A maioria dos procedimentos é executado no domicílio. A pesquisa em ambiente ambulatorial é o grande cenário de produção de conhecimento na área. As estratégias focadas em condutas físicas e funcionais são as mais demandadas na DP, com resultados aferíveis, ao passo que as intervenções baseadas em ocupações manifestam resultados discretos. Conclusão As atuações do terapeuta ocupacional na DP têm ampla variabilidade, ocorrem em diferentes contextos e seus desfechos sugerem que nem todas as opções mapeadas apresentam resultados consistentes ou não são suficientemente detalhadas para favorecer uma melhor interpretação dos achados.

Abstract Introduction Parkinson's disease (PD) ranks second among progressive chronic neurodegenerative diseases, with high prevalence and annual incidence. Therefore, it is necessary to update the current and developing occupational therapy options for this pathology. Objective To map the practices and approaches of occupational therapists conducted through therapeutic interventions in PD. Method Review conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist, based on the methodology of the Joanna Briggs Institute. The research question was formulated using the PCC (Patient, Concept, and Context) acronym, with primary and secondary terms consulted in the DeCS/MeSH multilingual thesaurus. Searches were conducted on five scientific databases between 2011 and 2020. Blind researchers were compared by the degree of agreement measured by Cohen's kappa coefficient. Results The findings indicate that there are at least eight categories of practices and approaches performed by occupational therapists in PD. Most procedures are conducted at home. Research in outpatient environments is the primary setting for knowledge production in the field. Strategies focused on physical and functional behaviors are most in demand in PD, with measurable results, while occupation-based interventions show modest results. Conclusion The actions of occupational therapists in PD are highly variable, occur in different contexts, and their outcomes suggest that not all mapped options present consistent results or are not sufficiently detailed to favor a better interpretation of the findings.

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Purpose: To compare biometric characteristics between patients with early-stage familial exudative vitreoretinopathy (FEVR) and healthy controls. Methods: This case-control study included 50 FEVR eyes in stage 1-2 and 50 control eyes matched by age, gender and spherical equivalent (SE). Biometric parameters including axial length (AL), white-to-white diameter (WTW), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), pupil diameter, vitreous chamber depth, anterior and posterior corneal surface curvature radius (ACR and PCR), anterior lens surface curvature radius (ALR) and posterior lens surface curvature radius were measured using IOLMaster 700 and compared between cases and controls using paired t-test. Correlations between SE and biometric measures were assessed using Pearson correlation coefficient (r) in cases and controls. Results: Both FEVR cases and matched controls had a mean age of 7.6 years, 48% female and mean SE of -5.3 D (80% myopia). Compared to controls, FEVR eyes had smaller AL (P = 0.009), WTW (P = 0.001), ACD (P < 0.001), and ALR (P = 0.03), but larger CCT (P = 0.02) and LT (P = 0.01). In FEVR eyes, SE was negatively correlated with AL (r = -0.79, P < 0.001), positively correlated with ACR (r = 0.29, P = 0.04) and PCR (r = 0.33, P = 0.02), whereas in controls, SE was negatively correlated with AL (r = -0.82, P < 0.001) and LT (r = -0.34, P = 0.02), positively correlated with ALR (r = 0.29, P = 0.04). Conclusions: Patients at early stage of FEVR exhibited a unique eye morphology resembling ocular development arrest, which may help to develop screening and early detection tools for FEVR. In FEVR patients, myopia is very prevalent and significantly associated with corneal curvature increase.

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Introducción. Las radiografías continúan usándose ampliamente, subestimando los riesgos. Esto sucede, especialmente, en las unidades de cuidado neonatal, lo que implica que los neonatos reciben una dosis de radiación ionizante mayor que los adultos. Objetivo. Cuantificar las dosis de radiación recibidas al tomar radiografías y evaluar los posibles factores asociados con el aumento de la dosis. Materiales y métodos. Se llevó a cabo un estudio observacional de 160 neonatos de la Unidad de Recién Nacidos del Hospital Universitario San Ignacio, Bogotá, Colombia. Se consideró como variable dependiente la dosis de entrada en piel por cada radiografía. Se hizo la caracterización de los pacientes, seguida de un análisis multivariado con regresión lineal múltiple para identificar factores asociados. Resultados. Se analizaron 160 pacientes y 492 radiografías en total. Entre los hallazgos más frecuentes, se encuentran: pacientes de sexo masculino (n=87; 54,4 %), nacimiento por cesárea (n=122; 76,3 %) e indicación de toma de radiografías por dificultad respiratoria (n=123; 24,9 %). El 1,8 % (n=9) de los pacientes no tenían una indicación para la toma de la radiografía. La radiografía más frecuente fue la de tórax (n=322; 65,4 %). La mayoría de las radiografías se tomaron con el equipo computarizado (n=352; 71,5 %) y no con el digital (n=140, 28,4 %). La mediana de la dosis de entrada en piel con el equipo computarizado fue de 0,112 mGy (0,022; 0,134 mGy) y, con el equipo digital, de 0,020 mGy (0,019, 0,022 mGy). Conclusiones. Se cuantificaron las dosis de radiación absorbida en neonatos, general y específica, con el equipo computarizado y el digital. Se identificaron mayores dosis con el equipo computarizado. Se reconoció la interacción entre el equipo computarizado con menores edades gestacionales corregidas como principal factor para el aumento de la dosis. Además, se reconoció la relación entre el equipo computarizado y una menor edad gestacional corregida, como principal factor para una mayor dosis.

Introduction. Radiographs are still widely used, underestimating the risks. This situation is frequent in neonatal care units, generating radiation doses than in adults. Objective. To quantify the received radiation doses when performing radiographs on neonates and the possible factors associated with higher doses. Materials and methods. We performed an observational study of 160 neonates from the newborn unit of the Hospital Universitario San Ignacio, Bogotá, Colombia. We considered the input dose of each radiograph as the dependent variable. Patients were characterized and a multivariate analysis with multiple linear regression was performed to identify associated factors. Results. We analyzed 160 newborns and 492 radiographs. The most frequent findings were male patients (n=87, 54.4%), cesarean delivery (n=122, 76.3%), and radiograph indication for respiratory distress (n=123, 24.9%). One-point eight percent of the patients (n=9) did not have radiograph indication. The most frequently taken radiograph was chest (322, 65.4%). Most radiographs were taken with a computerized equipment (n=352, 71.5%), compared to a digital one (n=140, 28.4%). The median input dose with computerized equipment was 0.112 mGy (0.022, 0.134 mGy), and with the digital equipment was 0.020 mGy (0.019, 0.022 mGy). Conclusions. The general and specific absorbed radiation doses were measured in neonates with a computerized and a digital equipment. We identified higher doses with the computerized equipment. In addition, it was recognized the correlation between computerized radiography equipment with lower corrected gestational ages as the main factor for dose increase.

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Uveal melanoma (UM) is the most common primary intraocular cancer in the adult population. Recent studies suggested that the NLRP3 inflammasome could be a therapeutic target for cutaneous melanoma (CM), but the role of NLRP3 in UM remains unknown. Here, we analyzed the NLRP3-IL-1ß axis in 5 UM and 4 CM cell lines. Expression of NLRP3 mRNA in UM and CM was low, and expression in UM was lower than in CM (P < 0.001). NLRP3 protein levels were below detection limit for all cell lines. UM exhibited lower baseline IL-1ß secretion than CM, especially when compared to the Hs294t cell line (P < 0.05). Bioinformatic analysis of human tumor samples showed that UM has significantly lower expression of NLRP3 and IL-1ß compared with CM. In conclusion, our work shows evidence of extremely low NLRP3 expression and IL-1ß secretion by melanoma cells and highlight differences between CM and UM.

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RESUMO. A autonomia privada existencial, como expressão da dignidade da pessoa humana, representa para o indivíduo a possibilidade de agir em conformidade com valores e significados eleitos essenciais na elaboração do seu projeto de vida. Neste estudo, seus autores, dois terapeutas ocupacionais, dois advogados e uma psicóloga, somam saberes e dialogam com intuito de demarcar a relevância da autonomia privada existencial nas condições de demência avançada, nos estados vegetativos permanentes e na iminência de morte. Na tarefa a que se propõem, os autores ponderam sobre suas experimentações e interlocuções enquanto profissionais de formação acadêmica diversificada, inclinados a ofertar espaços para comunicar vida e acolher dores. São apresentadas e discutidas as bases jurídicas da autonomia privada, assim como os pressupostos da Logoterapia de Viktor Frankl em defesa da liberdade de vontade e da dignidade no final da vida.

RESUMEN La autonomía existencial privada, como expresión de la dignidad de la persona humana, representa para el individuo la posibilidad de actuar de acuerdo con valores y significados elegidos esenciales en la elaboración de su proyecto de vida. En este estudio, sus autores, dos terapeutas ocupacionales, dos abogados y un psicólogo suman conocimiento y diálogo con el fin de demarcar la relevancia de la autonomía privada existencial en condiciones de demencia avanzada, en estados vegetativos permanentes y muerte inminente. En la tarea que proponen, los autores reflexionan sobre sus vivencias e interlocuciones como profesionales con una formación académica diversificada, inclinados a ofrecer espacios para comunicar la vida y acoger el dolor. Se presentan y discuten las bases legales de la autonomía privada, así como los supuestos de la Logoterapia de Viktor Frankl en defensa de la libertad de voluntad y dignidad al final de la vida.

ABSTRACT. Existential private autonomy, as an expression of the dignity of the human person, represents for the individual the possibility of acting in accordance with essential values and meanings for elaboration of their life project. The authors of this study, two occupational therapists, two lawyers and a psychologist gather their knowledge and dialogue to demarcate the relevance of existential private autonomy in conditions of advanced dementia, in permanent vegetative states and imminent death. In the task proposed, the authors pondered over their experiences and dialogues as professionals with a diversified academic background, inclined to provide spaces to communicate life and welcome pain. The legal bases of private autonomy are presented and discussed, as well as the assumptions of Viktor Frankl's Logotherapy in defense of freedom of will and dignity at the end of life.

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Resumo Introdução Ann Allart Wilcock, tendo como foco a ciência da ocupação, idealizou as dimensões ser, fazer, tornar-se e pertencer, relacionando saúde, bem-estar e ocupação. Em sua jornada acadêmica e profissional, buscou apresentar a interdependência das dimensões citadas com a pessoa e a comunidade. Quando uma pessoa sofre uma ruptura parcial ou total em suas ocupações, pode vir a sofrer repercussões biopsicossociais, espirituais e ocupacionais. O câncer ainda é visto como um diagnóstico relativo à morte, contudo, diante da identificação precoce, tratamentos e avanços em pesquisas, é possível promover bem-estar e qualidade de vida. Dentre os tratamentos, os cuidados paliativos possuem como um dos princípios garantir a integralidade nos cuidados, controle e manejo de sintomas, acompanhamento multiprofissional à pessoa, à família, aos cuidadores e à comunidade, do diagnóstico até o processo de luto pós-óbito. Objetivo Compreender as percepções das ocupações de pessoas em cuidados paliativos oncológicos, sob a perspectiva de Wilcock. Método Pesquisa qualitativa, com procedimento de pesquisa-ação, que realizou sete entrevistas semiestruturadas, no período de julho a agosto de 2022, em clínicas de cuidados paliativos. Resultados Os achados se apresentaram nas categorias de ser e fazer, expondo as percepções e relações ocupacionais da pessoa consigo e em seu entorno. Conclusão As relações do ser e fazer nos cotidianos e como o terapeuta ocupacional podem vir a identificar as ocupações prejudicadas por meio das dimensões e dar suporte à pessoa internada. Busca-se estimular novos saberes nas comunidades acadêmicas e profissionais com base no objeto de estudo em ocupação e nos contextos dos terapeutas ocupacionais no cenário nacional, bem como garantir uma prática baseada em evidências.

Abstract Introduction Ann Allart Wilcock, focusing on the occupational science, idealized the dimensions of being, doing, becoming and belonging, relating health, well-being, and occupation. In her academic and professional journey, she sought to present the interdependence of the dimensions with the person and community. When a person suffers a partial or total break in their occupations, they may suffer biopsychosocial, spiritual and occupational repercussions. Cancer is still seen as a diagnosis related to death, however, given early identification, treatments, and advances in research, it is possible to promote well-being and quality of life. Among the treatments, palliative care has as one of the principles to guarantee completeness in care, control and management of symptoms, multidisciplinary monitoring of the person, their family, caregivers, and community, from diagnosis to the post-death mourning process. Objective To understand the perceptions of occupations of people in oncological palliative care, from Wilcock's perspective. Method Qualitative research, with an action-research procedure. Seven semi-structured interviews were carried out from July to August 2022, in palliative care clinics. Results The findings were presented in the categories of being and doing, presenting the perceptions and occupational relationships of the person with themselves and their surroundings. Conclusion The relationships between being and doing in everyday life and how occupational therapists can identify impaired occupations through the dimensions and provide support to the hospitalized person. The aim is to stimulate new knowledge in academic and professional communities based on the object of study in occupation and the contexts of occupational therapists in the national scenario, as well as ensuring evidence-based practice.

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Ultraviolet light A (UVA) is the only UV light that reaches the retina and can cause indirect damage to DNA via absorption of photons by non-DNA chromophores. Previous studies demonstrate that UVA generates reactive oxygen species (ROS) and leads to programmed cell death. Programmed cell death (PCD) has been implicated in numerous ophthalmologic diseases. Here, we investigated receptor interacting protein 1 and 3 (RIPK1 and RIPK3) kinases, key signaling molecules of PCD, in UVA-induced photoreceptor injury using in vitro and ex vivo models. UVA irradiation activated RIPK3 but not RIPK1 and mediated necroptosis through MLKL that lie downstream of RIPK3 and induced apoptosis through increased oxidative stress. Moreover, RIPK3 but not RIPK1 inhibition suppresses UVA-induced cell death along with the downregulation of MLKL and attenuates the levels of oxidative stress and DNA fragmentation. In conclusion, these results identify RIPK3, not RIPK1, as a critical regulator of UVA-induced necroptosis cell death in photoreceptors and highlight RIPK3 potential as a neuroprotective target.

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BACKGROUND: Immunization is the key to prevent invasive meningococcal disease (IMD), caused by Neisseria meningitidis. Outer membrane vesicles (OMVs) can be used as meningococcal antigens. METHODS: Isogenic mice A/Sn (H2a) were immunized with low antigenic doses of OMVs of an N. meningitidis C:2a:P1.5 strain, via intranasal/intramuscular route, adjuvanted by cholera toxin subunit B (CTB) or via intramuscular route only, adjuvanted by aluminium hydroxide (AH). Mice were followed until old age and humoral and cellular responses were assessed by ELISA, Immunoblotting, Dot-blot, Serum-bactericidal assay, Immunohistochemistry and ELISpot. RESULTS: OMV+CTB and OMV+AH groups presented statistically higher antibodies titers, which persisted until middle and old ages. IgG isotypes point to a Th2 type of response. Avidity indexes were considered high, regardless of adjuvant use, but only groups immunized with OMVs and adjuvants (OMV+CTB and OMV+AH) presented bactericidal activity. The antibodies recognized antigens of molecular weights attributed to porin and cross-reactivity proteins. Although the spleen of old mice did not present differences in immunohistochemistry marking of CD68+, CD4+, CD79+ and CD25+ cells, splenocytes of immune groups secreted IL-4 and IL-17 when stimulated with OMVs and meningococcal C polysaccharide. CONCLUSION: We concluded that both adjuvants, CTB and AH, improved the immunogenicity of low doses of OMVs and contributed to a persistent immune response. Even though AH is well established in the vaccinology area, CTB seems to be a promising adjuvant candidate for meningococcal vaccines: it is suitable for mucosal delivery and supports a Th2 type of response. Therefore, OMVs are still a relevant vaccine platform.

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Objective The Schatzker classification is the most used for tibial plateau fractures. Kfuri et al. 12 reviewed Schatzker's initial classification describing in more detail the involvement of the tibial plateau in the coronal plane, allowing a better understanding of the fracture pattern and a more accurate surgical planning. The objectives of the present study are to evaluate the interobserver agreement of these classifications and to evaluate the influence of the experience of the observer on the reproducibility of the instruments. Methods An observational and retrospective study was conducted by evaluating the radiological study of 20 adult individuals with tibial plateau fractures, including radiographs and computed tomography (CT). The fractures were classified once by 34 examiners with varied experience (24 specialists and 10 residents in Orthopedics and Traumatology), according to the Schatzker classification and to the modification proposed by Kfuri. The Fleiss Kappa index was used to verify interobserver agreement. Results The interobserver agreement index was considered moderate for the Schatzker classification (κ = 0.46) and mild for the Kfuri modification (κ = 0.30). The Schatzker classification showed moderate agreement, with κ = 0.52 for residents and κ = 0.45 among specialists. The Kfuri classification showed mild agreement, with Kappa values for residents and specialists of 0.39 and 0.28, respectively. Conclusion The Schatzker classification and the classification modified by Kfuri presented moderate and mild interobserver agreement, respectively. In addition, the residents presented higher agreement than the specialists for the two systems studied.

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The meningococcal disease is a global health threat, but is preventable through vaccination. Adjuvants improve meningococcal vaccines and are able to trigger different aspects of the immune response. The present work evaluated the immune response of mice against Neisseria meningitidis outer membrane vesicles (OMV) complexed with the adjuvants aluminium hydroxide (AH), via subcutaneous route; and dimethyldioctadecylammonium bromide (DDA) or Saponin (Sap), via intranasal/subcutaneous routes. ELISA demonstrated that all adjuvants increased IgG titers after the booster dose, remaining elevated for 18 months. Additionally, adjuvants increased the avidity of the antibodies and the bactericidal titer: OMVs alone were bactericidal until 1:4 dilution but, when adjuvanted by Alum, DDA or Sap, it increased to 1/32. DDA and Sap increased all IgG isotypes, while AH improved IgG1 and IgG2a levels. Thus, Sap led to the recognition of more proteins in Immunoblot, followed by DDA and AH. Sap and AH induced higher IL-4 and IL-17 release, respectively. The use of adjuvants improved both cellular and humoral immune response, however, each adjuvant contributed to particular parameters. This demonstrates the importance of studying different adjuvant options and their suitability to stimulate different immune mechanisms, modulating the immune response.

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Environmental impacts are currently linked to smoking cigarette behavior, as cigarette butts (CBs) represent the most common litter item in natural areas. Despite this, even the best ranked Brazilian cities, in terms of urban cleaning, have no information about urban littered CBs. Thus, CBs were monitored in Santos and Niterói cities, aiming to assess contamination, Cigarette Butt Pollution Index (CBPI) and the illegal market size. CBs were collected in 36 walkways considering different land usage types and urban density levels. The CBPI was calculated, and brands were used to identify the size of the illegal market. CBs contamination in Santos (0.25 CBs/m2) was three times higher than Niterói (0.08 CBs/m2) and their occurrence and distribution presented no relationship with land usage types and urban population densities levels. CBPI = 17.6 was severe and the highest so far reported. A total of 28 cigarette brands were found both studied cities. Further, illegal cigarette consumption in Santos and Niteroi was estimated, based on brands of collected CBs, at 25.2% and 36.8%, respectively. Such data may be valuable for implementation of logistic reverse actions seeking to environmentally sustainable and socially resilient cities. Cigarette consumption threatens human life and the environment, and tobacco companies should be accountable for the pollution they generate.

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Vaccines are the most effective tool to control infectious diseases, which provoke significant morbidity and mortality rates. Most vaccines are administered through the parenteral route and can elicit a robust systemic humoral response, but they induce a weak T-cell-mediated immunity and are poor inducers of mucosal protection. Considering that most pathogens enter the body through mucosal surfaces, a vaccine that elicits protection in the first site of contact between the host and the pathogen is promising. However, despite the advantages of mucosal vaccines as good options to confer protection on the mucosal surface, only a few mucosal vaccines are currently approved. In this review, we discuss the impact of vaccine administration in different mucosal surfaces; how appropriate adjuvants enhance the induction of protective mucosal immunity and other factors that can influence the mucosal immune response to vaccines.

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Abstract Objective The Schatzker classification is the most used for tibial plateau fractures. Kfuri et al.12 reviewed Schatzker's initial classification describing in more detail the involvement of the tibial plateau in the coronal plane, allowing a better understanding of the fracture pattern and a more accurate surgical planning. The objectives of the present study are to evaluate the interobserver agreement of these classifications and to evaluate the influence of the experience of the observer on the reproducibility of the instruments. Methods An observational and retrospective study was conducted by evaluating the radiological study of 20 adult individuals with tibial plateau fractures, including radiographs and computed tomography (CT). The fractures were classified once by 34 examiners with varied experience (24 specialists and 10 residents in Orthopedics and Traumatology), according to the Schatzker classification and to the modification proposed by Kfuri. The Fleiss Kappa index was used to verify interobserver agreement. Results The interobserver agreement index was considered moderate for the Schatzker classification (κ = 0.46) and mild for the Kfuri modification (κ = 0.30). The Schatzker classification showed moderate agreement, with κ = 0.52 for residents and κ = 0.45 among specialists. The Kfuri classification showed mild agreement, with Kappa values for residents and specialists of 0.39 and 0.28, respectively. Conclusion The Schatzker classification and the classification modified by Kfuri presented moderate and mild interobserver agreement, respectively. In addition, the residents presented higher agreement than the specialists for the two systems studied.

Resumo Objetivo A classificação de Schatzker é a mais utilizada para as fraturas do planalto tibial. Kfuri et al.12 revisaram a classificação inicial de Schatzker descrevendo com mais detalhes o envolvimento do planalto tibial no plano coronal, permitindo uma melhor compreensão do padrão de fratura e um planejamento cirúrgico mais acurado. Os objetivos do presente estudo são avaliar a concordância inter-observador dessas classificações e avaliar a influência da experiência dos observadores na reprodutibilidade dos instrumentos. Métodos Foi realizado um estudo observacional e retrospectivo, por meio da avaliação do estudo radiológico de 20 indivíduos adultos com fraturas do planalto tibial, incluindo radiografias e tomografia computadorizada (TC). As fraturas foram classificadas 1 vez por 34 examinadores com experiência variada (24 especialistas e 10 residentes em Ortopedia e Traumatologia), de acordo com a classificação de Schatzker e com a modificação proposta por Kfuri. O índice Kappa de Fleiss foi usado para verificar a concordância interobservadores. Resultados O índice de concordância inter-observador foi considerado moderado paraa classificação de Schatzker (κ = 0,46) e leve para a modificação de Kfuri (κ = 0,30). A classificação de Schatzker apresentou concordância moderada, com κ = 0,52 para residentes e κ = 0,45 entre os especialistas. A classificação de Kfuri apresentou concordância leve com valores de Kappa para residentes e especialistas de 0,39 e 0,28, respectivamente. Conclusão A classificação de Schatzker e a classificação modificada por Kfuri apresentaram concordância interobservadores moderada e leve, respectivamente. Além disso, os residentes apresentaram concordâncias superiores aos especialistas para os dois sistemas estudados.

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Resumo O tratamento hospitalar das crianças com cardiopatias produz cerceamento das suas atividades rotineiras como banho, alimentação, escolarização e ludicidade; tal cerceamento se agravou durante a pandemia da COVID-19. Os protocolos de segurança do paciente e de biossegurança hospitalares que objetivam melhoria da qualidade das ações do cuidado e controle de infecção tendem a gerar uma realidade de anonimato, despersonalização, o que pode exacerbar a presença do temor relativo à dor e à ameaça de morte nos usuários e seus familiares. Os ambientes deste contexto que simbolizavam cuidados essenciais à vida agora passam a ser compreendidos, por parte da população, como o local de maior possibilidade de infecção pelo novo coronavírus. Este conjunto de fatores pode afetar a vida da criança cardiopata, diante da urgência da terapêutica hospitalar, influenciando negativamente na aceitação das intervenções realizadas neste contexto. Este artigo descreve a vivência sobre a atuação de uma residente de terapia ocupacional no programa em Atenção à Saúde Cardiovascular no contexto hospitalar durante a pandemia COVID-19, sobretudo no ano de 2020, em uma enfermaria pediátrica cardiológica. Trata-se de um estudo de caráter descritivo e cunho qualitativo do tipo relato de experiência profissional. Foi observado que a assistência e o cuidado às crianças e acompanhantes se tornaram restritos aos indivíduos que compartilhavam do mesmo ambiente de enfermaria e com os integrantes da equipe durante as intervenções. Diante disso, o terapeuta ocupacional se apresentou como o profissional habilitado para identificar rupturas no cotidiano, refletir e intervir em novas formas de atender às demandas ocupacionais e desenvolver recursos e adaptações que correspondessem às necessidades de cada usuário.

Abstract Hospital treatment of children with congenital heart disease during the SARS-CoV-2 pandemic restricts their daily activities such as bathing, eating, studying, and leisure. The protocols of patient safety and hospital biosafety that aim to improve the care quality actions and infection control tend to generate a reality of anonymity, depersonalization, which exacerbates the presence of fear related to pain and the threat of death in patients and their families. In this context, the environments that symbolized essential care for life now come to be understood by the population, as a place of the great possibility of infection by the new coronavirus. This set of factors can affect the lives of children with heart disease, given the urgency of hospital therapy, negatively influencing the acceptance of interventions performed in this context. To reflect on these aspects, this study describes the professional experiences that occurred during the COVID-19 pandemic in 2020 provided by a Cardiovascular Health Care Residency program. It is a descriptive and qualitative study of professional experience reports. In this, it was observed that the interaction of children and companions became restricted to individuals who shared the same ward environment and with the team members during the interventions. Because of this, the occupational therapist is the qualified professional to identify disruptions in daily life, reflect and intervene in new ways to meet occupational demands, develop resources and adaptations that corresponded to the needs of each patient.

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Resumo Objetivo Este estudo buscou compreender as ocupações de pessoas em tratamento para deixar de fumar. As motivações para tal pesquisa surgiram durante a prática como profissional residente em um Programa de Controle do Tabagismo. A fim de compreender as ocupações das pessoas participantes desse programa, utilizou-se uma perspectiva teórica sobre os sentidos e significados ocupacionais desenvolvida no contexto da Ciência Ocupacional. Método Trata-se de uma pesquisa qualitativa realizada em setembro e outubro de 2020 com quatro participantes que estavam em tratamento do tabagismo. Os dados foram analisados a partir da Análise de Conteúdo. Resultados Foi possível identificar e discutir sobre fumar como ocupação e os sentidos que levaram os participantes a fumar e deixar de fumar. Esses sentidos estão relacionados à cultura, contexto e fatores psicoemocionais, adoecimento e autopercepção de saúde. Além disso, os participantes identificaram o espaço de tratamento como um suporte para o momento de transição ocupacional. Conclusão Fumar é uma ocupação que precisa ser considerada no tratamento do tabagismo, pois a maneira como se lida com a transição ocupacional pode interferir na adesão ao tratamento.

Abstract Objective This study sought to understand the occupations of people undergoing smoking cessation treatment. The motivations for this research emerged during a resident professional practice in a Tobacco Control Program. A theoretical perspective on the functions and meanings of occupations in the context of Occupational Science was used to understand the occupations of the participants of this program. Method This is a qualitative study carried out with four people undergoing smoking cessation treatment from September to October 2020. Data were analyzed by Content Analysis. Results It was possible to identify and discuss smoking as an occupation and the meanings that have led the participants to smoke and stop smoking. These meanings are related to culture, psycho-emotional context and factors, illness, and self-perception of health. In addition, the participants identified the treatment space as a support for the moment of occupational transition. Conclusion Smoking is an occupation that needs to be considered during smoking cessation treatment, as how the occupational transition is addressed can interfere with treatment adherence.

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Resumo Situações vivenciadas como estressoras, tais como a morte de entes queridos, perda de emprego, sonhos, projetos e outros têm afetado direta ou indiretamente as ocupações rotineiras das pessoas, resultando em rupturas, mudanças e afastamentos das preferências ocupacionais diárias, tanto as externas como as realizadas no ambiente doméstico, o que pode impactar a pessoa e a maneira como se ocupa e participa da vida social. O presente artigo apresenta uma proposta de intervenção e cuidados nas condições de perdas significativas e luto e fomenta reflexões a esse respeito sob uma perspectiva ocupacional, correlacionando conceitos da Ciência da Ocupação, Logoterapia e Análise Existencial de Viktor Frankl. Para tanto, baseia-se na estratégia interventiva de cuidado no luto, denominada "Jardim de Ocupações", a qual emprega elementos como a metáfora e o desenho como possibilidades para criar aproximações com a fundamentação teórica ancorada na Ciência Ocupacional, sob a ótica da tensão existencial e valores de sentido de Viktor Frankl. Considera-se a proposta interventiva "Jardins de Ocupações" como um instrumento participativo, reflexivo, com potencial para aprofundar reflexões e compreensões sobre os sentidos de vida e o engajamento em ocupações ante às perdas sofridas.

Abstract Situations experienced as stressful, such as the death of loved ones, loss of jobs, dreams, projects and others, have directly or indirectly affected people's routinely occupations, resulting in disruptions, changes and withdrawals from daily occupational preferences - both externally and the ones carried out in the domestic environment - which can impact the person and the way in which they engage and participate in social life. This article presents a proposal for intervention and care in the conditions of significant loss and mourning and promotes reflections on this subject from an occupational perspective, correlating concepts from Occupation Science, Logotherapy and Existential Analysis by Viktor Frankl. Therefore, it is based on the interventional strategy of care in mourning, called "Garden of occupations", which uses elements such as metaphors and drawing as possibilities to create approximations with the theoretical foundation anchored in Occupational Science, from the perspective of existential tension and values of meaning by Viktor Frankl. The interventional proposal "Garden of occupations" is considered a participatory, reflective instrument, with the potential to deepen reflections and understandings about the meanings of life and engagement in occupations in the face of losses suffered.