RESUMEN
OBJECTIVE: To describe the implementation of an oral cancer screening program at the Barretos Cancer Hospital (BCH) and present the outcome based on data obtained from 2014 to 2020. MATERIALS AND METHODS: The residents of the Regional Health District of Barretos (DRS-V) were personally invited by community health agents or nurses, and among 13,973 people, 15,222 oral examinations were carried out over the years in 18 of its municipalities. Oral examinations were performed at the Mobile Dental Unit and at the Prevention Department of the BCH. Inclusion criteria were being 35 years of age or older, having a personal history of tobacco or alcohol consumption, or having a lesion in the oral cavity found by community health agent or self-reported, regardless of age or risk factors. RESULTS AND CONCLUSION: The main result of our study was the stages of oral cancer among screen detected cases were smaller compared to cases in the hospital registry, in the state and in Brazil. Oral cancer detection rate per 1,000 oral examinations was 10.7.The early stages of oral cancer found by screening in primary care facilities or using mobile units suggest that, when organized, screening may improve the prognosis of oral cancer.
Asunto(s)
Detección Precoz del Cáncer , Neoplasias de la Boca , Humanos , Neoplasias de la Boca/diagnóstico , Neoplasias de la Boca/epidemiología , Brasil/epidemiología , Detección Precoz del Cáncer/métodos , Masculino , Femenino , Persona de Mediana Edad , Adulto , Anciano , Tamizaje Masivo/métodosRESUMEN
OBJECTIVE: Keratocystic odontogenic tumors (KOTs) can be treated with Carnoy's solution, although this treatment modality is not free from complications. It is important to verify the incidence of complications after the use of Carnoy's solution and compare these with the literature. MATERIALS AND METHODS: This study verified the effects of a complementary treatment for KOTs and assessed the incidence of such complications as recurrence, infection, sequestrum formation, mandibular fracture, dehiscence, and neuropathy. RESULTS: Twenty-two KOTs treated with Carnoy's solution combined with peripheral ostectomy were included, and the follow-up period varied from 12 to 78months with a mean of 42.9months. Complications included recurrence (4.5%), dehiscence (22.7%), infection (4.5%), and paresthesia (18.2%). No difference was found among lesions associated (9.1%) or not (0%) with nevoid basal cell carcinoma syndrome (P>0.05). Dehiscence was influenced by marsupialization (P<0.05), and paresthesia was observed exclusively in cases of mandibular canal fenestration (P<0.01). CONCLUSIONS: Complementary treatment with Carnoy's solution and peripheral ostectomy appear to provide efficient treatment for KOTs. Complications originating from the use of the solution are less frequent and less serious than complications associated with cryotherapy. Neuropathy seems to be related to direct contact between the solution and the epineurium.
Asunto(s)
Ácido Acético/uso terapéutico , Cloroformo/uso terapéutico , Etanol/uso terapéutico , Fijadores , Tumores Odontogénicos/tratamiento farmacológico , Ácido Acético/efectos adversos , Adolescente , Adulto , Anciano , Niño , Cloroformo/efectos adversos , Terapia Combinada , Etanol/efectos adversos , Femenino , Fijadores/efectos adversos , Estudios de Seguimiento , Humanos , Masculino , Fracturas Mandibulares/etiología , Neoplasias Mandibulares/tratamiento farmacológico , Neoplasias Mandibulares/cirugía , Nervio Mandibular/efectos de los fármacos , Nervio Mandibular/fisiopatología , Neoplasias Maxilares/tratamiento farmacológico , Neoplasias Maxilares/cirugía , Persona de Mediana Edad , Recurrencia Local de Neoplasia/patología , Tumores Odontogénicos/cirugía , Osteotomía/efectos adversos , Parestesia/etiología , Complicaciones Posoperatorias , Estudios Retrospectivos , Dehiscencia de la Herida Operatoria/etiología , Infección de la Herida Quirúrgica/etiología , Sensación Térmica/fisiología , Factores de Tiempo , Tacto/fisiología , Traumatismos del Nervio Trigémino/etiología , Adulto JovenRESUMEN
Salivary gland dysfunction is a common sequela of hematopoietic progenitor cell transplantation (HPCT). The investigation of major salivary gland dysfunction with sodium pertechnetate scintigraphy is a non-invasive method that provides images of the parotid and submandibular glands. In this prospective trial, 20 HPCT patients were submitted to scintigraphic study with 99mTc-pertechenate and 67Ga in order to evaluate the major salivary glands early involvement following HPCT. Major salivary glands were evaluated prior to HCPT as well as at Days +30, +60 and +100 post transplant. Major salivary glands uptake and clearance of 99mTc-pertechenate results did not demonstrate any functional differences between pre- versus post transplant periods. Results of the 67Ga scan revealed inflammatory infiltration following HPCT, primarily in submandibular glands, suggest a persistent involvement of major salivary glands up to Day +100 after HPCT.
Asunto(s)
Trasplante de Células Madre Hematopoyéticas/métodos , Cintigrafía/métodos , Glándulas Salivales/diagnóstico por imagen , Glándulas Salivales/lesiones , Trasplante Homólogo/métodos , Adulto , Femenino , Galio/metabolismo , Enfermedad Injerto contra Huésped , Trasplante de Células Madre Hematopoyéticas/efectos adversos , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Glándulas Salivales/metabolismo , Glándula Submandibular/metabolismo , Tecnecio/metabolismo , Trasplante Homólogo/efectos adversos , Resultado del Tratamiento , Xerostomía/etiología , Xerostomía/metabolismoRESUMEN
BACKGROUND: The established pathologic criteria for minor salivary gland (MSG) involvement in chronic graft-vs.-host disease (cGVHD) could play a role in monitoring response to therapy. METHODS: We evaluated MSG sequential biopsies during cGVHD therapy in 14 allogeneic bone marrow transplantation (BMT) patients. Nine patients that did not develop GVHD after BMT entered the control group. Biopsies were examined using hematoxylin-eosin, Periodic acid-Schiff (PAS) and leukocyte common antigen staining. RESULTS: A significant loss of PAS+ acinar volume was observed at the diagnosis of cGVHD as much as at the end of treatment when compared with the control group. In the second evaluation, the inflammatory infiltrate was still greater than control group. CONCLUSIONS: The results suggest that persistent xerostomia after cGVHD treatment is because of maintenance of lymphocytic infiltrate and consequent absence of MSG secretory unit recovery. This data may be useful to provide improved insight into the histopathology of this organ involvement.