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JCO Glob Oncol ; 7: 577-584, 2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33891480

RESUMEN

PURPOSE: The COVID-19 pandemic is a colossal challenge for global health; nonetheless, specific subgroups face considerably higher risks for infection and mortality. Among patients with malignant diseases, those with hematologic neoplasms are at a higher risk for poor outcomes. The objective of this study was to register treatment modifications associated with the COVID-19 pandemic and their short-term consequences in Latin America. METHODS: Multicenter, prospective, observational, cohort study including patients older than 14 years from 14 centers in four countries (Mexico, Peru, Guatemala, and Panama) who had a confirmed diagnosis of acute leukemia, and who were undergoing active treatment since the first COVID-19 case in each country until the cutoff on July 15, 2020. RESULTS: We recruited 635 patients. Treatment modifications because of the COVID-19 pandemic were reported in 40.8% of cases. The main reason for such modifications was logistic issues (55.0%) and the most frequent modification was chemotherapy delay (42.0%). A total of 13.1% patients developed COVID-19 disease, with a mortality of 37.7%. Several factors were identified as independently associated with mortality, including a diagnosis of acute myeloid leukemia (odds ratio 2.38 [95% CI, 1.47 to 3.84]; P < .001), while the use of telemedicine was identified as a protective factor (odds ratio 0.36 [95% CI, 0.18 to 0.82]; P = .014). CONCLUSION: These results highlight the collateral damage of COVID-19 in oncology patients.


Asunto(s)
COVID-19/prevención & control , Leucemia Mieloide/terapia , Oncología Médica/métodos , SARS-CoV-2/aislamiento & purificación , Enfermedad Aguda , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , COVID-19/epidemiología , COVID-19/virología , Comorbilidad , Epidemias , Femenino , Guatemala/epidemiología , Humanos , Leucemia Mieloide/diagnóstico , Leucemia Mieloide/epidemiología , Masculino , México/epidemiología , Persona de Mediana Edad , Panamá/epidemiología , Perú/epidemiología , Estudios Prospectivos , SARS-CoV-2/fisiología , Adulto Joven
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