RESUMEN

Apoptosis resistance is a hallmark of human cancer, and tumor cells often become resistant due to defects in the programmed cell death machinery. Targeting key apoptosis regulators to overcome apoptotic resistance and promote rapid death of tumor cells is an exciting new strategy for cancer treatment, either alone or in combination with traditionally used anti-cancer drugs that target cell division. Here we present a multiscale modeling framework for investigating the synergism between traditional chemotherapy and targeted therapies aimed at critical regulators of apoptosis.

Asunto(s)

Antineoplásicos/farmacología , Supervivencia Celular/efectos de los fármacos , Modelos Biológicos , Neoplasias/tratamiento farmacológico , Neoplasias/patología , Antineoplásicos/farmacocinética , Apoptosis/efectos de los fármacos , Cisplatino/farmacocinética , Cisplatino/farmacología , Resistencia a Antineoplásicos , Humanos , Conceptos Matemáticos , Neoplasias/metabolismo , Proteínas Proto-Oncogénicas c-bcl-2/antagonistas & inhibidores , Proteína bcl-X/antagonistas & inhibidores