RESUMEN

We report that females of some substrains of inbred mouse strain 129 are resistant to systemic plague due to conditionally virulent Deltapgm strains of Yersinia pestis; however, fully virulent Y. pestis is not attenuated in these mice. Therefore, these mice offer a powerful system in which to map in parallel host resistance traits and opposing bacterial virulence properties for plague.

Asunto(s)

Inmunidad Innata/genética , Peste/inmunología , Peste/microbiología , Yersinia pestis/genética , Yersinia pestis/inmunología , Animales , Femenino , Predisposición Genética a la Enfermedad , Masculino , Ratones , Ratones Endogámicos , Mutación , Peste/genética , Peste/mortalidad , Yersinia pestis/patogenicidad