RESUMEN

Here we report the preparation of a trimethoprim/2-hydroxypropyl-γ-cyclodextrin inclusion complex along with a physicochemical study, structural characterization, and molecular modeling of the complex. As main results, we observed from phase-solubility studies at two temperatures (20 °C and 35 °C) that the association constants decrease with increasing temperature. Values for K(1:1) constant were of the same magnitude order of those found for the parent γ-CD. The inclusion orientation as evidenced by ROESY measurements involves the inclusion of the 3,4,5-trimethoxybenzyl ring in the CD cavity from the larger rim. This is in agreement with semiempirical molecular modeling calculation.

Asunto(s)

Fenómenos Químicos , Trimetoprim/química , gamma-Ciclodextrinas/química , Glucosa/química , Cinética , Modelos Moleculares , Transición de Fase , Solubilidad , Espectroscopía Infrarroja por Transformada de Fourier , Temperatura