Asunto(s)
Alérgenos/inmunología , Antígenos/inmunología , Olea/inmunología , Agricultura/métodos , Humanos , Hipersensibilidad/diagnóstico , Hipersensibilidad/inmunología , Microscopía Electrónica , Óptica y Fotónica , Polen/ultraestructura , Prueba de Radioalergoadsorción , Pruebas Cutáneas , Especificidad de la EspecieRESUMEN
We compared the efficacy and tolerance of Azelastine nasal spray (0.14 mg in each nostril twice a day) versus Ebastine tablets (10 mg) as a single night dose in a Phase IV open, randomized, parallel-group clinical trial lasting 14 days, conducted with 63 patients diagnosed of seasonal allergic rhinitis. The symptoms assessed before and after the treatment period were: sneezing, nasal pruritus, rhinorrhea, nasal obstruction, conjunctival erythema, eye pruritus, eye watering, photophobia, pharyngeal pruritus and cough. Each symptom was rated by the patients according to a 4-point scale: absent: 0, mild: 1, moderate: 2, and severe: 3. The score required to be included in the study was 8 or above. In addition, the resistance of nasal fossae was assessed, before and after the treatment, by active anterior rhinomanometry, as well as the appearance of adverse events. Both drugs were equally effective both in the control of symptoms and in decreasing the airway resistance and no statistically significant differences were observed in the variables tested in both groups. We concluded that Azelastine nasal spray is a treatment as effective as Ebastine in the relief of symptoms of seasonal allergic rhinitis, with an excellent tolerance and minimum adverse effects.
Asunto(s)
Butirofenonas/administración & dosificación , Antagonistas de los Receptores Histamínicos H1/administración & dosificación , Ftalazinas/administración & dosificación , Piperidinas/administración & dosificación , Rinitis Alérgica Estacional/tratamiento farmacológico , Adolescente , Adulto , Butirofenonas/efectos adversos , Femenino , Antagonistas de los Receptores Histamínicos H1/efectos adversos , Humanos , Masculino , Persona de Mediana Edad , Nebulizadores y Vaporizadores , Ftalazinas/efectos adversos , Piperidinas/efectos adversos , ComprimidosRESUMEN
We have divided ninety three patients in two groups, accordingly to their symptomatology. After getting each patient Alpha 1 Antitrypsin phenotype by means of Isoelectrofocusing with polyacrylamyde plates (pH 4-5), it was verified that the group without Atopic Dermatitis had more MS phenotypes in statistically significant quantities (p less than 0.005) and those with Atopic Dermatitis showed more variety of MZ phenotypes (p less than 0,025). That is why we outline that, thanks to individual conditionings a single pathogenic mechanism may preferently take place in each case leading us to conclude that the Atopy may be considered as a Syndrome more than an illness.