RESUMEN
Nonradiologist health care providers have enjoyed the privilege of film interpretation without the assistance of radiologists. However, encroachment on the radiologist's turf of radiological image interpretation by nonradiologist physicians and radiographer technicians is reminiscent of recent antitrust battles between anesthesiologists and nurse anesthetists. Numerous antitrust issues are relevant to radiology; however, the scope of this article is limited to antitrust issues most relevant to radiology turf battles. Such battles often raise antitrust issues of group boycotts, tying arrangements, and exclusive contracts.
Asunto(s)
Leyes Antitrust , Radiología/legislación & jurisprudencia , Convenios Médico-Hospital/legislación & jurisprudencia , Atención al Paciente , Calidad de la Atención de Salud , Radiología/organización & administración , Estados UnidosRESUMEN
This overview addresses the controversial practice of reuse and reprocessing of single-use medical devices and the issues this practice raises for physician liability. Specifically, we describe the health risks associated with medical device reprocessing, analyze the market costs arising from the reuse and reprocessing of single-use medical devices, and discuss physician liability for failure to obtain informed consent of the patient for the use of reprocessed single-use medical devices.
Asunto(s)
Equipo Reutilizado/legislación & jurisprudencia , Consentimiento Informado/legislación & jurisprudencia , Responsabilidad Legal , Equipos Desechables/normas , Equipo Reutilizado/economía , Humanos , Texas , Estados Unidos , United States Food and Drug AdministrationAsunto(s)
Seguridad de Productos para el Consumidor , Equipos Desechables , Equipo Reutilizado/legislación & jurisprudencia , Responsabilidad Legal , Equipos Desechables/economía , Contaminación de Equipos/prevención & control , Equipo Reutilizado/economía , Humanos , Medición de Riesgo , Estados Unidos , United States Food and Drug AdministrationRESUMEN
Subunit interactions of the alpha1- and beta1-subunits of the chicken Na,K-ATPase were explored with the yeast two-hybrid system. Gal4-fusion proteins containing domains of the alpha1- and beta1-subunits were designed for examining both intersubunit and intrasubunit protein-protein interactions. Regions of the alpha- and beta-subunits known to be involved in alpha-beta-subunit assembly were positive in two-hybrid assay, supporting the validity of the assays. A library of beta-subunit ectodomains with C-terminal truncations was screened to find the maximal truncation retaining an interaction with the alpha-subunit extracellular H7H8 loop (where H7 refers to the seventh membrane span, and so on). The maximal truncation removed all the cysteines involved in disulfide bridges, leaving only 63 amino acids of the beta-subunit ectodomain. Scanning alanine mutagenesis led to identification of an evolutionarily conserved sequence of four amino acids (SYGQ) in the extracellular H7H8 loop of the alpha-subunit that is crucial to alpha-beta-intersubunit interactions. Oligomerization studies with single domains failed to detect self-association of either of the two large cytosolic loops (H2H3 and H4H5) within the alpha-subunit. However, evidence was found for an interaction between these two cytoplasmic loops.