RESUMEN
The Blood Transfusion Service introduced screening for Hepatitis C antibody (HCV) in September 1991. This is done by second generation enzyme linked immunosorbent assay (ELISA) tests. We present a case of post-transfusion hepatitis C hepatitis in a patient with myeloma. Infection was acquired before screening was introduced. Both the patient and the infected blood donor were diagnosed using ELISA assays and the polymerase chain reaction (PCR). In this way we prevented the blood donor from spreading the virus via subsequent blood donations. There were some interesting discrepancies in the HCV assays. Blood samples, when tested by different methods, gave both positive and negative results. The results also varied according to when the blood samples to be tested were taken. The case illustrates the importance of confirming positive results and that no single laboratory test is entirely satisfactory in diagnosing HCV infection.
Asunto(s)
Hepatitis C/etiología , Reacción a la Transfusión , Anciano , Donantes de Sangre , Ensayo de Inmunoadsorción Enzimática , Hepacivirus/aislamiento & purificación , Anticuerpos Antihepatitis/sangre , Hepatitis C/transmisión , Anticuerpos contra la Hepatitis C , Humanos , Masculino , Reacción en Cadena de la PolimerasaRESUMEN
A case is described of a 67-year-old man with chronic myeloid leukemia and a "masked" Philadelphia chromosome due to a translocation between chromosomes #4 and #22. The significance of this case in relation to the possible pathogenesis of chronic myeloid leukemia is discussed.