RESUMEN
The effect of phenol on the rat kidney was investigated by means of an arterial infusion designed to deliver isotonic phenol solutions directly to the renal circulation. Cortical lesions, consisting primarily of vacuolization and dilation of proximal tubules and sloughing of the apical cytoplasm, increased in severity with increasing phenol dose. Specific staining techniques allowed the detection of effects on the brush borders and basement membranes of tubules. Evidence was also offered for hemolysis products not reaching the proximal tubules. These findings are consistent with a direct effect of phenol on the kidney.
Asunto(s)
Enfermedades Renales/inducido químicamente , Fenoles/toxicidad , Animales , Tasa de Filtración Glomerular , Enfermedades Renales/patología , Túbulos Renales/efectos de los fármacos , Masculino , Fenol , Ratas , Ratas Endogámicas , Circulación Renal/efectos de los fármacos , Ácido p-Aminohipúrico/metabolismoRESUMEN
Abnormal platelet function in patients with chronic renal failure has been associated with elevated levels of phenol and phenolic acids in serum. In vitro studies show inhibition of secondary aggregation by phenol, suggesting that phenol acts at the platelet release reaction. When platelet rich plasma was incubated with phenol, inhibition was found to decrease with increasing preincubation time at 37 degrees C, but not at 0 degree C. Also, the inhibitory effect of phenol in vitro was overcome by the addition of arachidonic acid. These findings demonstrate inhibition of secondary aggregation by phenol. Thus the site of the inhibitory action of phenol was at the initiation of the secondary wave of platelet aggregation.