RESUMEN
Pure RBC aplasia (PRCA) and myasthenia gravis (MG) are occasionally associated with thymoma, although the occurrence of all three in a single patient is rare. We describe a patient in whom PRCA and MG occurred in conjunction with the presence of serum autoantibodies, evidence for a serum inhibitor of erythropoiesis, and elevation of circulating thymosin alpha 1. Although a thymoma could not be detected before death, postmortem examination of the mediastinum found scattered cells within a nodule, suggestive of a lymphoepithelial thymic neoplasm.
Asunto(s)
Anemia Aplásica/complicaciones , Miastenia Gravis/complicaciones , Timoma/complicaciones , Anciano , Femenino , Humanos , Timoma/fisiopatologíaAsunto(s)
Adulto , Persona de Mediana Edad , Humanos , Masculino , Femenino , Técnicas In Vitro , Vacunas contra la Influenza , PolirradiculoneuropatíaRESUMEN
The Clausen modification of the peripheral blood buffy coat leukocyte migration test was used to test patients with multiple sclerosis, normal subjects and patients with other neurologic diseases for cell-mediated immunity to commercial measles virus, purified nuclear core material from a human neurotropic strain of measles virus, as well as to commercial preparations of rubella, mumps and parainfluenza HA2. Leukocytes of multiple sclerosis patients showed significantly less mean inhibition of migration in the presence of both measles antigens, mumps and parainfluenza but no difference from controls when incubated with rubella. No correlation could be found between the degree of migration inhibition and concomitant serum anti-measles neutralization antibody titers to the same strain of virus. The use of purified viral antigens might result in more meaningful studies of the status of cellmediated immunity to viral antigens in multiple sclerosis. The relationship of our findings to other studies in this area and to the pathogenesis of multiple sclerosis is discussed.
Asunto(s)
Leucocitos/inmunología , Virus del Sarampión , Esclerosis Múltiple/inmunología , Anticuerpos Antivirales , Inhibición de Migración Celular , Femenino , Humanos , Masculino , Enfermedades del Sistema Nervioso/inmunologíaRESUMEN
In five patients with definite multiple sclerosis and lack of cell-mediated immunity to measles and parainfluenza virus antigens, various immunological parameters were studied before and during transfer factor treatment. The study showed that cell-mediated immunity to measles virus antigen, as evaluated by the leukocyte migration agarose test, could temporarily be restored, using repeated injections of transfer factor pooled from unselected, normal blood donors.
Asunto(s)
Esclerosis Múltiple/terapia , Factor de Transferencia/uso terapéutico , Formación de Anticuerpos , Antígenos Virales/análisis , Inmunidad Celular , Activación de Linfocitos , Linfocitos/inmunología , Sarampión/inmunología , Esclerosis Múltiple/inmunología , Infecciones por Paramyxoviridae/inmunologíaRESUMEN
The Clausen modification of the leukocyte migration test was used to test patients with multiple sclerosis, normal subjects, and patients with other neurologic diseases for cell-mediated immunity to 6/94 virus (a parainfluenza virus previously isolated from the brain tissue of a multiple sclerosis patient), c-RNA virus isolated from a tumor, and the nonviral antigens Candida and purified protein derivative. Leukocytes of multiple sclerosis patient showed significantly less mean inhibition of migration by the 6/94 virus (but not by the c-RNA virus, purified protein derivative, and Candida) than did the cells of normal controls and patients with other neurologic diseases. The relationship of these findings to previous observations in this area and to the pathogenesis of multiple sclerosis is discussed.