RESUMEN
OBJECTIVE: Endothelial specific molecule 1 (Endocan) is a biomarker of the inflammatory process occurring in endothelial cells. It was shown that endocan was increased in acute coronary syndromes. We aimed at investigating the endocan levels in acute coronary syndrome patients after coronary bypass surgery. PATIENTS AND METHODS: The study included 35 patients who presented with acute coronary syndrome to the Emergency Department. Serum endocan levels and other inflammatory markers were evaluated before and after coronary artery by-pass surgery. The correlation coefficients and their significance were calculated by Pearson's test and the difference in mean values before and after bypass surgery was calculated by paired sample t-test. Statistical analyses were performed using SPSS version 20.0 (SPSS Inc., Chicago, IL, USA). Statistical significance was taken as p<0.05. RESULTS: There was a significant change in serum hs-CRP and endocan levels and also LVEF before and after CABG operation (p<0.05). CONCLUSIONS: Serum endocan level was significantly decreased after successful reperfusion in our study. Thus, it may be an important biomarker in terms of clinical use as an indicator of successful reperfusion.
Asunto(s)
Síndrome Coronario Agudo/cirugía , Puente de Arteria Coronaria , Reperfusión Miocárdica , Proteínas de Neoplasias/sangre , Proteoglicanos/sangre , Síndrome Coronario Agudo/sangre , Síndrome Coronario Agudo/diagnóstico , Anciano , Biomarcadores/sangre , Biomarcadores/metabolismo , Proteína C-Reactiva/análisis , Angiografía Coronaria , Vasos Coronarios/citología , Vasos Coronarios/diagnóstico por imagen , Vasos Coronarios/metabolismo , Estudios Transversales , Células Endoteliales/metabolismo , Endotelio Vascular/citología , Endotelio Vascular/metabolismo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Proteínas de Neoplasias/metabolismo , Periodo Posoperatorio , Periodo Preoperatorio , Proteoglicanos/metabolismo , Volumen Sistólico , Resultado del TratamientoRESUMEN
INTRODUCTION: Our aim was to investigate the relationship between serum omentin-1 levels and endothelial dysfunction in obese patients. MATERIAL AND METHODS: We evaluated 50 obese patients, and age/gender matched 45 healthy non-obese subjects as controls. Oral glucose tolerance test, lipid parameters, uric acid levels, homeostatic model assessment-insulin resistance (HOMA-IR) index, serum omentin-1 levels and flow mediated dilatation (FMD) % were measured in all subjects. Body compositions were analyzed with bioelectrical impedance method using a Tanita Body Composition Analyzer and ViScan. RESULTS: Serum omentin-1 levels were found significantly lower in obese population compared to the control subjects. FMD response was significantly decreased in obese population. There was a significant positive correlation between serum omentin-1 levels and FMD response (r=0.359, p<0.001). Serum omentin-1 levels were negatively correlated with body mass index (BMI), waist circumference, total fat percentage, visceral fat, fasting insulin and HOMA-IR index. CONCLUSION: Lower serum omentin-1 levels and decreased FMD response may be an early marker of endothelial dysfunction in obese patients.
RESUMEN
AIM: The aim of this cross-sectional study was to determine whether pilonidal sinus is influenced by hormones that stimulate body hair growth. Currently, there are insufficient data on the presence of hormonal abnormalities in pilonidal sinus disease. METHOD: Hormone levels (including those of thyroid-stimulating hormone, follicular-stimulating hormone, luteinizing hormone, prolactin, progesterone, oestradiol, testosterone, cortisol and dehydroepiandrosterone) were measured in 39 patients with pilonodal sinus presenting between February 2013 and March 2013. The results were compared with those of 39 volunteers without this disease. RESULTS: There was no statistically significant difference between men with pilonidal sinus disease (P > 0.05). The prolactin levels of women with pilonoidal sinus were significantly higher than those of women in the control group (P < 0.05). CONCLUSION: Raised serum prolactin levels in women may be related to the development of pilonidal sinus disease.
Asunto(s)
Hormonas/sangre , Seno Pilonidal/sangre , Adolescente , Adulto , Estudios de Casos y Controles , Estudios Transversales , Deshidroepiandrosterona/sangre , Estradiol/sangre , Femenino , Hormona Folículo Estimulante/sangre , Humanos , Hidrocortisona/sangre , Hormona Luteinizante/sangre , Masculino , Persona de Mediana Edad , Progesterona/sangre , Prolactina/sangre , Testosterona/sangre , Tirotropina/sangre , Adulto JovenRESUMEN
BACKGROUND: Hepatitis C infection occurs frequently among patients with end-stage renal disease and increases the risk of atherosclerotic cardiovascular diseases. Endothelial dysfunction (ED) is an early event in the pathogenesis of atherosclerosis. It has been reported among patients treated with hemodialysis (HD), peritoneal dialysis (PD), or renal transplantation. The aim of the present study was to evaluate effects of chronic hepatitis C infection on ED in patients with failed renal transplants. METHODS: Twenty-six nondiabetic, anti-hepatitis C virus (HCV)-positive (15 females, mean age: 38 +/- 8 years) and 26 anti-HCV-negative patients (15 females, mean age: 36 +/- 5 years), all of whom had returned to PD or HD after renal transplant failure were studied to assess coronary flow reserve (CFR) by transthoracic Doppler echocardiography. Serum high-sensitivity C-reactive protein (hs-CRP) levels were measured as markers of chronic inflammation. CFR recordings and intima-media thickness measurements were performed using the Vivid 7 echocardiography device. RESULTS: Demographic and clinical characteristics of patients were similar between the two groups. Serum hs-CRP levels were significantly higher among HCV-positive patients versus HCV-negative counterparts. HCV-positive patients showed lower CFR measurement than HCV-negative ones. Also, a negative correlation was observed between serum hs-CRP levels and CFR values. CONCLUSION: CFR values are worse among anti-HCV-positive patients with failed renal transplants compared with anti-HCV-negative subjects. Graft dysfunction per se may aggravate a proinflammatory states thereby inducing ED. Furthermore, the presence of HCV is a greater trigger of ED among patients with renal failed grafts.
Asunto(s)
Circulación Coronaria/fisiología , Hepatitis C Crónica/complicaciones , Hepatitis C Crónica/fisiopatología , Trasplante de Riñón/fisiología , Diálisis Peritoneal , Diálisis Renal , Adulto , Presión Sanguínea , Proteína C-Reactiva/metabolismo , Ecocardiografía , Femenino , Humanos , Inflamación/fisiopatología , Trasplante de Riñón/patología , Masculino , Diálisis Peritoneal Ambulatoria Continua , Insuficiencia del Tratamiento , Túnica Íntima/patología , Túnica Media/patologíaRESUMEN
Neurofibromatosis (NF) is a hereditary disease and carries increased risk of both benign and malignant tumor development. Pheochromocytoma or hyperparathyroidism have been reported to be associated with NF type 1 (NF1). However, the coexistance of pheochromocytoma and parathyroid adenoma in a patient with NF1 is very rare. We report a case of a 37-year-old male with NF1, bilateral pheochromocytoma and parathyroid adenoma. This association sould be kept in mind in patients with NF1 in initial evaluation as well as during follow-up.
Asunto(s)
Neoplasias de las Glándulas Suprarrenales/complicaciones , Hiperparatiroidismo Primario/complicaciones , Neurofibromatosis/complicaciones , Feocromocitoma/complicaciones , Adenoma/complicaciones , Neoplasias de las Glándulas Suprarrenales/diagnóstico por imagen , Adulto , Humanos , Hiperparatiroidismo Primario/diagnóstico por imagen , Masculino , Neoplasias de las Paratiroides/complicaciones , Feocromocitoma/diagnóstico por imagen , Radiografía , CintigrafíaRESUMEN
The metric values of the foramen magnum (FM) were studied both by dry skull measurements and tomographic measurements. Anteroposterior (AP) and transverse diameters of 88 skulls in three different groups were taken into consideration. The mean AP value for the 38 skulls of the first group (Late Byzantine Era, A.D. 13th century) was 35.6 +/- 2.3 mm, while the mean transverse value was 29.9 +/- 2.1 mm. Twenty-seven skulls of the 20th century had the mean values of 35.1 +/- 2.8 and 28.7 +/- 2.2 mm for AP and transverse measurements, respectively. The third group consisted of computed tomography (CT) measurements of 23 outpatients in the radiology department. Their mean AP value was 36.4 +/- 2.8 and the mean transverse value was 30.0 +/- 1.4 mm. When the measurements of 88 skulls of the three groups were considered together, the mean AP value was 35.6 +/- 2.7 and the transverse value was 29.5 +/- 2.1 mm. There is no significant difference between the total mean value of the present study and that of other authors. However, if the three groups are considered separately, the mean transverse value shows significant differences, especially that of the second group. Also the radiographic and tomographic measurements of other authors have higher results than the present results, perhaps due to methodologic differences.
Asunto(s)
Foramen Magno/anatomía & histología , Antropología Física , Antropometría , Humanos , TurquíaRESUMEN
The location and number of the diaphysial dominant nutrient foramina in 305 specimens of the human lower limb long bones were examined. The diaphysial nutrient foramina on the femur were located at between 26.7-84.4% of the total length; while on the tibia between 11.0-67.2%; and on the fibula between 29.8-67.8% of the total length. The number of the diaphysial nutrient foramina and their distribution on the faces of each bone was also studied.