RESUMEN

Merkel cell carcinoma (MCC) is recognized by its morphologic features and by its classic immunophenotypic properties. Although MCCs demonstrating nonclassic immunoreactivities have been described, a case documenting a change in immunophenotype during the course of disease progression has not been previously reported. We report a case of MCC that initially demonstrated cytokeratin 20 positivity but lost expression in subsequent metastases. Likewise, thyroid transcription factor-1 was initially negative in the tumor but expression was present in metastatic lesions.

Asunto(s)

Biomarcadores de Tumor/análisis , Neoplasias Encefálicas/química , Neoplasias Encefálicas/secundario , Carcinoma de Células de Merkel/química , Carcinoma de Células de Merkel/secundario , Proteínas Nucleares/análisis , Neoplasias Cutáneas/química , Factores de Transcripción/análisis , Anciano , Biopsia , Neoplasias Encefálicas/terapia , Carcinoma de Células de Merkel/terapia , Progresión de la Enfermedad , Humanos , Inmunohistoquímica , Queratina-20/análisis , Masculino , Valor Predictivo de las Pruebas , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/terapia , Factor Nuclear Tiroideo 1