RESUMEN

We present the case of a 55-year-old woman who sustained a left femoral neck fracture which was managed by insertion of a dynamic hip screw. Six hours after surgery, distension appeared in the left lower quadrant of her abdomen associated with a decline in haemoglobin concentration and clinical signs of ongoing bleeding. Computed tomography showed a left retroperitoneal mass without concomitant extravasation of contrast material. Exploratory laparotomy revealed a damaged left obturator artery with a large haematoma in its vicinity. After arterial ligation and retroperitoneal space decompression her postoperative course was uneventful. Reviewing intraoperative C arm images a 0.8 cm protrusion of the threaded guide wire was identified as the cause of obturator artery damage.

Asunto(s)

Arteria Femoral/lesiones , Fijación de Fractura/efectos adversos , Fracturas de Cadera/cirugía , Complicaciones Posoperatorias , Lesiones del Sistema Vascular/etiología , Femenino , Arteria Femoral/diagnóstico por imagen , Humanos , Persona de Mediana Edad , Tomografía Computarizada por Rayos X , Procedimientos Quirúrgicos Vasculares/métodos , Lesiones del Sistema Vascular/cirugía

RESUMEN

We have re-screened the genes for the 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT7 serotonin receptors for genetic variants in a large African-American and Caucasian-American population sample. We have identified eight novel variants in these genes including four that are predicted to cause amino acid substitutions. These variants are additional candidates for association studies of behavioral disorders such as depression and schizophrenia as well as quantitative personality traits. We have also detected some, but not all, previously identified variants in these genes suggesting that many previously identified variants are unique to specific populations. The results of this study, and previous screens of serotonin receptors, demonstrate that the genes for serotonin receptors display marked population and molecular genetic complexity. These levels of complexity may have a substantial effect on genetic association studies of human behavioral variability related to these genes. We discuss the implications of these findings and propose methods to address complexity in genetic association studies.

Asunto(s)

Variación Genética , Receptores de Serotonina/genética , Negro o Afroamericano/genética , Alelos , Secuencia de Aminoácidos , ADN/química , ADN/genética , Análisis Mutacional de ADN , Frecuencia de los Genes , Pruebas Genéticas , Haplotipos/genética , Humanos , Trastornos Mentales/diagnóstico , Trastornos Mentales/genética , Datos de Secuencia Molecular , Polimorfismo de Nucleótido Simple , Receptor de Serotonina 5-HT1A/genética , Receptor de Serotonina 5-HT2A/genética , Receptor de Serotonina 5-HT2C/genética , Homología de Secuencia , Población Blanca/genética