RESUMEN

Major pharmacokinetic parameters of the Soviet anticonvulsive drug benzobarbital used with different regimens of administration (single and prolonged) are described. The authors have studied the interrelationship between benzobarbital and carbamazepine when these drugs are used in combination and drawn a conclusion as to their weak pharmacokinetic synergism. On the basis of the established pharmacokinetic parameters a number of practical inferences pertaining to the mode of benzobarbital administration have been made.

Asunto(s)

Anticonvulsivantes/farmacocinética , Barbitúricos/farmacocinética , Anticonvulsivantes/análisis , Anticonvulsivantes/uso terapéutico , Barbitúricos/análisis , Barbitúricos/uso terapéutico , Química Encefálica , Carbamazepina/análisis , Carbamazepina/farmacocinética , Carbamazepina/uso terapéutico , Cromatografía de Gases , Relación Dosis-Respuesta a Droga , Interacciones Farmacológicas , Quimioterapia Combinada , Epilepsia/tratamiento farmacológico , Epilepsia/metabolismo , Semivida , Humanos , Saliva/análisis , Factores de Tiempo