RESUMEN
In this study we have investigated the immune humoral response in the associated vaccination with smallpox, tetanus and typhoid fractionated vaccine (trivaccine) administered in two series at 1 month interval, by dermojet, in a group of young people of 18-20 years old. The results were comparatively estimated with those obtained in two groups of young people of the same age (control group), separately immunized with two components of the tri-vaccine: fractionated smallpox vaccine and tetanus toxoid, following-up the humoral response to the two vaccine components. It was find that, at the end of the surveillance period, similar results were obtained for the testing group and control group, the antibody titers (in geometric mean) presenting very close values: 1/1,140,463 for the testing group, and 1/1,053,583 for the control group against vaccinia component, and 1/1,86,880,586 for the testing group and 1/79,900,431 for the control group, against the tetanus component. The results obtained entitle us to propose this vaccination scheme for the vaccination practice.
Asunto(s)
Antígenos Virales/inmunología , Vacuna contra Viruela/inmunología , Toxoide Tetánico/inmunología , Vacunas Tifoides-Paratifoides/inmunología , Virus Vaccinia/inmunología , Adolescente , Adulto , Anticuerpos Antibacterianos/análisis , Anticuerpos Antivirales/análisis , Formación de Anticuerpos/inmunología , Antígenos Virales/administración & dosificación , Clostridium tetani/inmunología , Pruebas de Hemaglutinación , Humanos , Inmunización Secundaria , Inyecciones a Chorro , Vacuna contra Viruela/administración & dosificación , Solubilidad , Toxoide Tetánico/administración & dosificación , Toxoide Tetánico/aislamiento & purificación , Factores de Tiempo , Vacunas Tifoides-Paratifoides/administración & dosificación , Vacunas de Productos Inactivados/administración & dosificación , Vacunas de Productos Inactivados/inmunologíaAsunto(s)
Vacunas contra el Cólera/administración & dosificación , Animales , Anticuerpos Antibacterianos/análisis , Embrión de Pollo , Vacunas contra el Cólera/inmunología , Evaluación Preclínica de Medicamentos , Femenino , Calor , Inmunización/métodos , Inyecciones Intradérmicas , Inyecciones Subcutáneas , Masculino , Conejos , Factores de Tiempo , Vacunas de Productos Inactivados/administración & dosificación , Vacunas de Productos Inactivados/inmunología , Vibrio cholerae/inmunologíaRESUMEN
Revaccination against smallpox was performed by three techniques: double scarification, multiple puncture and jet injection in 352 youths aged 16 and 17 years. The results were assessed by the number of takes, the quality of the cutaneous and humoral response. The highest proportion of major skin reactions was obtained by multiple puncture vaccination (62.4%) and the best humoral response, tested by passive haemagglutination, by jet revaccination. Multiple puncture is recommended as a method of election both in restricted and mass vaccination in view of the high proportion of major skin rections accompanied by a corresponding humoral response, the rapid and readily performed technique and small amount of vaccine needed.