RESUMEN
Some proteolytic inhibitors were shown to be able to suppress the growth and development of a series of bacterial agents, the drug gordox being the most active among them. The effects of proteolytic inhibitors on the course of an inflammatory process experimentally simulated were studied. Endolymphatic (intranodular) injection of proteolytic inhibitors increased the activity of agents responsible for the body's nonspecific resistance and sharply reduced intoxication, by providing effective treatment of inflammation.
Asunto(s)
Bacterias/efectos de los fármacos , Inflamación/tratamiento farmacológico , Inhibidores de Proteasas/farmacología , Hidrólisis , Inflamación/microbiologíaRESUMEN
The immune status of 73 pregnant women and puerperae, administered proteolysis inhibitors or common antibacterial therapy to prevent pyoseptic complications, was assessed before cesarean section and 1 and 7 days after it. The results indicate certain shifts in the immunity status of puerperae of all groups, which were the most expressed 1 day after surgery (reduced content of CD3 lymphocytes, IgG and IgA, and a marked increase of the content of C-reactive protein) and normalized by day 7 postoperation. These changes are most likely to be caused by the surgical intervention but not the infectious inflammatory process, which is proved by the absence of pyoseptic complications after prophylactic measures taken. Hence, proteolysis inhibitors, along with the traditional methods, may be recommended for the prevention of pyoseptic complications after cesarean section.
Asunto(s)
Formación de Anticuerpos/efectos de los fármacos , Cesárea/efectos adversos , Inmunidad Celular/efectos de los fármacos , Inhibidores de Proteasas/uso terapéutico , Trastornos Puerperales/prevención & control , Infección Puerperal/prevención & control , Adulto , Proteína C-Reactiva/análisis , Femenino , Humanos , Inmunoglobulina A/análisis , Inmunoglobulina G/análisis , Inmunoglobulina M/análisis , Inflamación , Embarazo , Cuidados Preoperatorios , Inhibidores de Proteasas/farmacología , Trastornos Puerperales/inmunología , Infección Puerperal/inmunología , Supuración , Subgrupos de Linfocitos TRESUMEN
Donor plasma irradiated by ultraviolet rays was administered intravenously to patients with choledocholithiasis, chronic hepatitis and liver cirrhosis. Parameters of the acid-base balance of arterialized capillary blood shifted to alkalosis, were normalized, and tension of carbon dioxide and oxygen in the blood increased to physiological values. Dynamic changes of the biochemical parameters demonstrated alleviation of manifestations of the cholestasis syndrome.
Asunto(s)
Equilibrio Ácido-Base , Sangre/efectos de la radiación , Colestasis/radioterapia , Cálculos Biliares/radioterapia , Hepatopatías/radioterapia , Terapia Ultravioleta , Adulto , Anciano , Colestasis/complicaciones , Colestasis/metabolismo , Femenino , Cálculos Biliares/complicaciones , Cálculos Biliares/metabolismo , Humanos , Hepatopatías/complicaciones , Hepatopatías/metabolismo , Masculino , Persona de Mediana EdadRESUMEN
The method of intravenous administration of UV-irradiated donor plasma to patients with jaundice of different genesis has been tested in the experiments on rats and used clinically in 20 patients. Biochemical and morphological studies have shown that such treatment causes stable improvement in the liver functional state.