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1.
Parasitology ; 144(2): 124-130, 2017 02.
Artículo en Inglés | MEDLINE | ID: mdl-27894367

RESUMEN

Strongyloides venezuelensis is a parasitic nematode of rodents that is frequently used to obtain heterologous antigens for immunological diagnosis of human strongyloidiasis. The aim of this study was to identify antigens from filariform larvae of S. venezuelensis for immunodiagnosis of human strongyloidiasis. Soluble and membrane fractions from filariform larvae of S. venezuelensis were obtained in phosphate saline (SS and SM) and in Tris-HCl buffer (TS and TM), and were analysed by Western blotting. Different antigenic components were recognized by IgG antibodies from the sera of strongyloidiasis patients. Highest recognition was observed for a 30-40 kDa mass range present in all antigenic fractions. The band encompassing this mass range was then excised and subjected to mass spectrometry for protein identification. Immunoreactive proteins identified in the soluble fractions corresponded to metabolic enzymes, whereas cytoskeletal proteins and galectins were more abundant in the membrane fractions. These results represent the first approach towards identification of S. venezuelensis antigens for use in immunodiagnostic assays for human strongyloidiasis.


Asunto(s)
Strongyloides/inmunología , Estrongiloidiasis/sangre , Estrongiloidiasis/diagnóstico , Animales , Antígenos Helmínticos , Biomarcadores/sangre , Ensayo de Inmunoadsorción Enzimática , Proteínas del Helminto/inmunología , Humanos , Sensibilidad y Especificidad , Estrongiloidiasis/inmunología
2.
J Helminthol ; 89(4): 465-70, 2015 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-24725503

RESUMEN

Toxocara canis and Toxocara cati are nematode parasites in dogs and cats, respectively, transmitted by ingestion of embryonated eggs, transmammary and transplacental (T. canis) routes and paratenic host predation. Many parasites use mechanisms that change the behaviour of their hosts to ensure continued transmission. Several researchers have demonstrated behavioural changes in mouse models as paratenic hosts for T. canis. However, there have been no studies on behavioural changes in laboratory rats (Rattus norvegicus) experimentally infected with T. cati. This study investigated behavioural changes and muscle strength in male and female rats experimentally infected with T. cati or T. canis in acute and chronic phases of infection. Regardless of sex, rats infected with T. cati showed a greater decrease in muscle strength 42 days post infection compared to rats infected with T. canis. However, behavioural changes were only observed in female rats infected with T. canis.


Asunto(s)
Conducta Animal , Fuerza Muscular , Toxocara/fisiología , Toxocariasis/patología , Animales , Femenino , Masculino , Ratas
3.
Biomed Res Int ; 2015: 1-16, 2015. ilus
Artículo en Inglés | Sec. Est. Saúde SP, LILACS, SESSP-IALPROD, Sec. Est. Saúde SP, SESSP-IALACERVO | ID: biblio-1022429

RESUMEN

Schistosomiasis constitutes a major public health problem, with an estimated 200 million people infected worldwide. Many areas of Brazil show low endemicity of schistosomiasis, and the current standard parasitological techniques are not sufficiently sensitive to detect the low-level helminth infections common in areas of low endemicity (ALEs). This study compared the Kato-Katz (KK); Hoffman, Pons, and Janer (HH); enzyme-linked immunosorbent assay- (ELISA-) IgG and ELISA-IgM; indirect immunofluorescence technique (IFT-IgM); and qPCR techniques for schistosomiasis detection in serum and fecal samples, using the circumoval precipitin test (COPT) as reference. An epidemiological survey was conducted in a randomized sample of residents from five neighborhoods of Barra Mansa, RJ, with 610 fecal and 612 serum samples. ELISA-IgM (21.4%) showed the highest positivity and HH and KK techniques were the least sensitive (0.8%). All techniques except qPCR-serum showed high accuracy (82­95.5%), differed significantly from COPT in positivity , and showed poor agreement with COPT. Medium agreement was seen with ELISA-IgG (Kappa = 0.377) and IFA (Kappa = 0.347). Parasitological techniques showed much lower positivity rates than those by other techniques. We suggest the possibility of using a combination of laboratory tools for the diagnosis of schistosomiasis in ALEs.


Asunto(s)
Esquistosomiasis mansoni/diagnóstico , Esquistosomiasis mansoni/parasitología , Esquistosomiasis mansoni/epidemiología , Anciano de 80 o más Años , Brasil/epidemiología , Anciano , Humanos , Inmunoensayo/métodos , Inmunoensayo/estadística & datos numéricos , Pruebas de Precipitina/métodos , Niño , Preescolar , Vigilancia de la Población/métodos , Prevalencia , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Medición de Riesgo/métodos , Adulto , Técnicas de Laboratorio Clínico/métodos , Técnicas de Laboratorio Clínico/estadística & datos numéricos , Enfermedades Endémicas/estadística & datos numéricos , Adulto Joven , Lactante , Persona de Mediana Edad
4.
Parasitology ; 141(5): 716-21, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-24476900

RESUMEN

Strongyloidiasis is frequently asymptomatic and diagnosis of latent infection is difficult due to limitations of current parasitological and serological methods. This study aimed to verify the use of conventional polymerase chain reaction (PCR) assay for molecular diagnosis of Strongyloides stercoralis infection. Fresh stool samples were obtained from 103 individuals: 33 S. stercoralis positive, 30 positive for other parasites and 40 negative for parasitological methods. These samples were examined by the Lutz, Rugai and agar plate culture methods and conventional PCR assay. Two sets of primers (S. stercoralis species-specific and genus-specific sets), located in the 18S ribosomal RNA gene, were used for PCR. Of the 33 samples positive for S. stercoralis by parasitological methods, 28 (84.8%) were also detected by PCR assay using species-specific primers and 26 (78.8%) using genus-specific primers. Among the stool samples negative by parasitological methods, seven (17.5%) were positive by PCR using species-specific primers and two (5.0%) using genus-specific primers. In conclusion, the conventional PCR assay described in this study using a species-specific primer pair provided a molecular method for S. stercoralis diagnosis in human stool samples.


Asunto(s)
Reacción en Cadena de la Polimerasa/métodos , Strongyloides stercoralis/aislamiento & purificación , Estrongiloidiasis/diagnóstico , Animales , Cartilla de ADN/genética , ADN de Helmintos/química , ADN de Helmintos/genética , ADN Ribosómico/química , ADN Ribosómico/genética , Heces/parasitología , Humanos , ARN Ribosómico 18S/genética , Sensibilidad y Especificidad , Especificidad de la Especie , Strongyloides stercoralis/genética , Estrongiloidiasis/parasitología
6.
Gastroenterol Hepatol ; 28(1): 30-9, 2005 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-15691467

RESUMEN

In the present review, we will discuss the Schistosoma mansoni form, which is the most widely distributed schistosome in humans and is found both in the Old and New Worlds. The main features of the natural history of mansonic schistosomiasis are reviewed, with emphasis on the clinical forms of the disease, their diagnosis and treatment.


Asunto(s)
Esquistosomiasis mansoni/diagnóstico , Enfermedad Aguda , Enfermedad Crónica , Humanos , Esquistosomiasis mansoni/complicaciones , Esquistosomiasis mansoni/tratamiento farmacológico , Esquistosomiasis mansoni/parasitología
7.
Rev Inst Med Trop Sao Paulo ; 43(3): 153-9, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-11452324

RESUMEN

The circumoval precipitin test (COPT), enzyme-linked immunosorbent assay (ELISA) and the immunoblotting anti-adult worm antigen (AWA) and soluble egg antigen (SEA) tests were applied to 17 chronically schistosome-infected patients for the detection of anti-Schistosoma mansoni antibodies before and on four occasions after oxamniquine administration over a period of six months. Compared to a control group, schistosomiasis patients showed high levels of IgG antibodies in AWA and SEA-ELISA. A decrease in IgG levels was observed six months after treatment, although negative reactions were not obtained. Significant decreases in IgG1, IgG3 and, mainly, IgG4, but not anti-SEA IgG2 levels were observed six months after treatment, again without negativity. Analysis of anti-AWA IgG antibodies by immunoblotting before treatment showed a 31 kDa strand in 14 patients (82%) which disappeared in three cases up to six months after treatment; furthermore, anti-SEA IgG antibodies showed the same band in nine patients (53%) before treatment, which disappeared in only four cases up to six months after treatment.


Asunto(s)
Anticuerpos Antihelmínticos/sangre , Inmunoglobulina G/sangre , Schistosoma mansoni/inmunología , Esquistosomiasis mansoni/inmunología , Adolescente , Adulto , Anciano , Análisis de Varianza , Animales , Antígenos Helmínticos , Enfermedad Crónica , Ensayo de Inmunoadsorción Enzimática , Femenino , Estudios de Seguimiento , Humanos , Immunoblotting , Masculino , Persona de Mediana Edad , Oxamniquina/uso terapéutico , Esquistosomiasis mansoni/tratamiento farmacológico , Esquistosomicidas/uso terapéutico
8.
Mem Inst Oswaldo Cruz ; 95(5): 711-2, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-10998221

RESUMEN

The frequency of coinfection with Strongyloides stercoralis and human T-cell leukemia/lymphoma virus type 1 (HTML-1) was determined in 91 blood donors examined at the blood bank of a large hospital in São Paulo city, Brazil. As control group 61 individuals, not infected by HTLV-1, were submitted to the same techniques for the diagnosis of S. stercoralis infection. In HTLV-1 infected patients the frequency of S. stercoralis infection was 12.1%; on the other hand, the control group showed a frequency significantly lower of S. stercoralis infection (1.6%), suggesting that HTLV-1 patients should be considered as a high risk group for strongyloidiasis in São Paulo city.


Asunto(s)
Donantes de Sangre , Virus Linfotrópico T Tipo 1 Humano/aislamiento & purificación , Leucemia-Linfoma de Células T del Adulto/complicaciones , Strongyloides stercoralis/aislamiento & purificación , Estrongiloidiasis/complicaciones , Animales , Humanos , Leucemia-Linfoma de Células T del Adulto/sangre , Leucemia-Linfoma de Células T del Adulto/epidemiología , Factores de Riesgo , Estrongiloidiasis/sangre , Estrongiloidiasis/epidemiología
9.
Rev Inst Med Trop Sao Paulo ; 42(6): 313-20, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-11136517

RESUMEN

PURPOSE: To evaluate the frequency and the consequences of the co-infection of hepatitis B and C viruses in patients with hepatosplenic schistosomiasis (HSS). METHODS: B and C serologic markers, exposure to risk factors, biochemical assays, upper gastrointestinal endoscopies, and abdominal ultrasonograms were evaluated in 101 patients with HSS from 1994 to 1997. Whenever possible, PCR was tested and histopathological studies were reviewed. RESULTS: At least one HBV virus marker was found in 15.8%, and anti-HCV was detected in 12.9% of the subjects. The seropositive subjects tended to be older than the seronegative ones. A history of blood transfusion was significantly related to the presence of anti-HCV. Three (18.75%) out of 16 subjects exposed to B virus were HBsAg positive. Eleven (84.6%) out of thirteen patients who were anti-HCV positive demonstrated viral activity. Patients with ongoing viral infection presented a higher average level of liver aminotransferases, a higher frequency of cell decompensation and a higher rate of chronic hepatitis. Portal hypertension parameters were not influenced by viral exposure. CONCLUSIONS: The rate of hepatitis B and C viruses serologic markers observed in the patients with HSS was higher than the control group. The co-infection was responsible for a higher frequency of cell decompensation.


Asunto(s)
Anticuerpos contra la Hepatitis B/sangre , Anticuerpos contra la Hepatitis C/sangre , Esquistosomiasis mansoni/inmunología , Enfermedades del Bazo/inmunología , Adulto , Anciano , Biomarcadores/sangre , Estudios de Casos y Controles , Distribución de Chi-Cuadrado , Femenino , Hepatitis B/complicaciones , Hepatitis B/inmunología , Hepatitis C/complicaciones , Hepatitis C/inmunología , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Esquistosomiasis mansoni/complicaciones , Enfermedades del Bazo/complicaciones , Enfermedades del Bazo/parasitología , Estadísticas no Paramétricas
10.
J Pediatr (Rio J) ; 75(2): 97-104, 1999.
Artículo en Portugués | MEDLINE | ID: mdl-14685548

RESUMEN

OBJECTIVES: To observe the occurrence of different etiological agents of acute diarrhea (AD) in stool specimens of patients and children in a control group. MATERIAL AND METHODS: 100 children less than three years of age with AD were studied as well as 100 controls, between November 1993 and May 1994. Stool specimens were collected in both groups and the following enteropathogens were searched for: Rotavirus, Escherichia coli (EPEC, ETEC, EIEC, EHEC), Salmonella sp, Shigella sp, Campylobacter jejuni, Campylobacter coli, Yersinia enterocolitica, Cryptosporidium sp, Giardia lamblia, Entamoeba histolytica. Statistical analysis using the exact Fisher test (at significance level p<0,05) was done. The mean age was 12,5 months, with more cases in patients less than 6 months (35%). Children were seen at the emergency section on an average fifth day after the start of the diarrhea. Most came from homes with basical sanitary conditions. Watery diarrhea was more frequent than bloody diarrhea with mucus, at a proportion of 4:1. RESULTS: Rotavirus was the most frequent agent: 21% in the AD group and 3% in the control group (p= 0,0001). Shigella sp was isolated in 7% of the AD group and none of the control group (p= 0,0140). EPEC was detected in 13% of AD cases and 7% in the control group (p= 0,2381) but the classical subgroups O55, O111, O119 were only isolated from the patients with AD. The other enteropathogens were infrequently detected or in equal proportion in both groups. Rotavirus and EPEC were the more frequently isolated agents in watery diarrhea, while Shigella sp was the predominant agent found in bloody stools with mucus. CONCLUSIONS: Rotavirus was the most common causative agent in AD. The detection of Rotavirus and Shigella sp nearly exclusively in patients with AD confirms the high patogenicity of these etiological agents when compared to the others. Escherichia coli (EPEC) diagnosed by polyvalent sera does not confirm its respective diarrheogenic property due to isolation in the same proportion among patients with AD and controls. Monovalent antisera made possible the detection of classical subgroups of EPEC O111, O119, O55 isolated only from AD patients, confirming the already known high patogenicity of these strains.

11.
Rev Inst Med Trop Sao Paulo ; 40(3): 165-71, 1998.
Artículo en Inglés | MEDLINE | ID: mdl-9830730

RESUMEN

A cross-sectional study on the prevalence of schistosomiasis mansoni in three sites of the "Baixada Ocidental Maranhense" was carried out in 1993 in: Alegre (in the municipality of São Bento), Aliança (in Cururupu) and Coroatá II (in the municipality of São João Batista). Results were compared to those of another study performed at the same sites and in similar conditions, in 1987. The entire population of the three sites, with few exceptions, was submitted to fecal tests using the Kato-Katz method and immediate intradermal tests for schistosomiasis in both studies. Subjects with positive results in one of these tests were clinically evaluated by a physical examination. In 1993, the total of 827 subjects were submitted to fecal examination and 826 to intradermal test. Schistosoma mansoni eggs were found in the feces of 154 (18.6%) subjects, while 478 (57.9%) subjects presented a positive intradermal test. Stool examination was carried out in 367 subjects in Alegre with a positivity rate of 14.9%; the intradermal test, performed in 366 subjects, was positive in 47.5% of the cases. In Aliança, 277 subjects had their feces examined and were submitted to an intradermal test, with a positivity rate of 34.4% and 70.7%, respectively. Finally in Coroatá II, 183 inhabitants submitted to fecal and intradermal tests had positivity rates of 2.2% and 59.0%, respectively. When the present data were compared to those obtained in the survey performed in 1987, a significant decrease in the prevalence of infection by S. mansoni was observed in Alegre and Coroatá II, and a prevalence increase in Aliança.


Asunto(s)
Esquistosomiasis mansoni/epidemiología , Adolescente , Animales , Brasil , Estudios Transversales , Femenino , Humanos , Pruebas Intradérmicas , Masculino , Recuento de Huevos de Parásitos , Prevalencia , Schistosoma mansoni/inmunología
13.
Rev Soc Bras Med Trop ; 31(4): 333-7, 1998.
Artículo en Inglés | MEDLINE | ID: mdl-9662959

RESUMEN

The frequency of infection by Cryptosporidium parvum was determined in two groups of renal patients submitted to immunosuppression. One group consisted of 23 renal transplanted individuals, and the other consisted of 32 patients with chronic renal insufficiency, periodically submitted to hemodialysis. A third group of 27 patients with systemic arterial hypertension, not immunosuppressed, was used as control. During a period of 18 months all the patients were submitted to faecal examination to detect C. parvum oocysts, for a total of 1 to 6 tests per patient. The results showed frequencies of C. parvum infection of 34.8%, 25% and 17.4%, respectively, for the renal transplanted group, the patients submitted to hemodialysis and the control group. Statistical analysis showed no significant differences among the three groups even though the frequency of C. parvum infection was higher in the transplanted group. However, when the number of fecal samples containing C. parvum oocysts was taken in account, a significantly higher frequency was found in the renal transplanted group.


Asunto(s)
Criptosporidiosis/parasitología , Cryptosporidium parvum , Fallo Renal Crónico/parasitología , Trasplante de Riñón , Diálisis Renal , Animales , Criptosporidiosis/epidemiología , Cryptosporidium parvum/aislamiento & purificación , Heces/parasitología , Femenino , Humanos , Hipertensión/parasitología , Terapia de Inmunosupresión , Incidencia , Fallo Renal Crónico/terapia , Masculino
15.
Rev Inst Med Trop Sao Paulo ; 39(3): 171-4, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9460259

RESUMEN

Since the beginning of the seventies the natural transmission of Chagas' infection has been considered to be under control in the State of São Paulo and not even a case of American Trypanosomiasis, transmitted by triatomine bugs, has been detected by the epidemiological surveillance system. This situation justifies the report of a case of acute Chagas' disease that occurred in a forest area considered free of domiciliary triatomines along the Southern seacoast of São Paulo State. In May, 1995 the presence of trypomastigote forms of Trypanosoma cruzi had been diagnosed in a retired 57 year-old male patient, born and living in Santos (São Paulo State), complaining of fever, fatigue and malaise. The patient reported that 40 days before he had participated with 17 friends in a 7-day excursion in a forest area of the municipalities of Itanhaém and Peruíbe. During this period the group had been lodged in three houses located within the forest. Eight days after the end of the excursion the patient began to have fever, malaise and fatigue. During the next 31 days he had received medical care both as an inpatient and an outpatient, without any significant improvement. After the detection of T. cruzi trypomastigotes in his blood stream the patient began to be treated with benzonidazole in a hospital but died 8 days after the beginning of treatment. The epidemiological investigation carried out showed no signs of the presence of triatomine bugs in the three houses where the group had been lodged, or any indication of Chagas' infection in other excursionists.


Asunto(s)
Enfermedad de Chagas/epidemiología , Enfermedad Aguda , Brasil/epidemiología , Humanos , Masculino , Persona de Mediana Edad
16.
Rev Inst Med Trop Sao Paulo ; 39(3): 159-63, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9460257

RESUMEN

Mebendazole, albendazole, levamisole and thiabendazole are well known as active drugs against several nematode species, and against cestodes as well, when the first two drugs are considered. None of the drugs have proven activity, however, against trematodes. We tested the effect of these drugs on the fecal shedding of schistosome eggs and the recovering of adult schistosomes, after portal perfusion in Schistosoma mansoni experimentally infected mice. Balb/c mice infected with 80 S. mansoni cercariae were divided into three groups, each in turn subdivided into four other groups, for each tested drug. The first group was treated with each one of the studied drugs 25 days after S. mansoni infection; the second group was submitted to treatment with each one of the drugs 60 days after infection. Finally, the third group, considered as control, received no treatment. No effect upon fecal shedding of S. mansoni eggs and recovering of schistosomes after portal perfusion was observed when mice were treated with either mebendazole or albendazole. Mice treated with either levamisole or thiabendazole, on the other hand, showed a significant reduction in the recovering of adult schistosomes after portal perfusion, mainly when both drugs were given during the schistosomula evolution period, i.e., 25 days after cercariae penetration, probably due to unspecific immunomodulation.


Asunto(s)
Antihelmínticos/farmacología , Bencimidazoles/farmacología , Modelos Animales de Enfermedad , Schistosoma mansoni/efectos de los fármacos , Esquistosomiasis/tratamiento farmacológico , Tiazoles/farmacología , Animales , Femenino , Masculino , Ratones , Ratones Endogámicos BALB C
17.
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;29(4): 373-6, Jul.-Aug. 1996. tab
Artículo en Portugués | LILACS | ID: lil-187159

RESUMEN

We relate a case of an 18-year-old man, resident of Xapuri (state of Acre, Brazil), with a history of repeated episodes of meningoencephalitis (three in one year), each one was examined by a local doctor. In our service (Emílio Ribas Institute of Infectology) we observed a patient with polyjoint aches, radiological and bronchoscopic pulmonary alterations (without clinical features), meningeal and brain stem manifestations--with normal brain computed tomography and cerebrospinal fluid. Blood eosinophils and serological Toxocara canis test (ELISA) were greatly increased. With the hypothesis of Toxocariasis (visceral larva migrans) we administered thiabendazole that brought complete clinical and laboratory remission. Inspite of a new episode of headache with meningeal manifestation approximately one month later (treated with dexamethasone resulting in a full remission after three days) we have not found other manifestations in approximately three and a half years of ambulatory care.


Asunto(s)
Humanos , Animales , Masculino , Adolescente , Larva Migrans Visceral/diagnóstico , Toxocara canis , Anticuerpos Antihelmínticos/sangre , Antinematodos/administración & dosificación , Brasil , Enfermedad Crónica , Dexametasona/uso terapéutico , Glucocorticoides/uso terapéutico , Larva Migrans Visceral/complicaciones , Larva Migrans Visceral/tratamiento farmacológico , Recurrencia , Tiabendazol/administración & dosificación , Toxocara canis/inmunología
18.
Rev Inst Med Trop Sao Paulo ; 38(4): 265-71, 1996.
Artículo en Inglés | MEDLINE | ID: mdl-9216107

RESUMEN

The clinical and epidemiologic aspects of infection with Ascaris lumbricoides were studied in a random stratified sample of the population of the subdistrict of Cavacos, municipality of Alterosa (Minas Gerais, Brazil). The effect of mass treatment with a single dose of albendazole on the prevalence and intensity of infection was also studied six months later in the same population. During the first phase of the study, a questionnaire was applied to 248 individuals to obtain information about the socioeconomic, sanitary and clinical conditions of the population surveyed. A total of 230 fecal samples were also examined by the Kato-Katz technique in order to determine the intensity of A. lumbricoides infection. Two hundred and two individuals were simultaneously submitted to blood counts and 70 children aged 12 years or less were evaluated for nutritional status. The presence of A. lumbricoides and other helminth eggs was also determined in 22 soil samples collected in the urban zone of Cavacos. Infection with enteroparasitic helminths was detected in 29.1% of the sample, with a predominance of A. lumbricoides (23.9%). Parasitism and/or intensity of A. lumbricoides infection were significantly correlated with age range (15 years or less), social class, sanitary and living conditions (water, sewage and domiciliary area per person), and presence of abdominal pain. However, these parameters were not correlated with nutritional status or hematocrit levels. During the second phase of the study, a slight but not statistically significant decrease in the prevalence of A. lumbricoides infection was detected after treatment with albendazole. However, an important and significant reduction in the amount of A. lumbricoides eggs eliminated through the feces was detected, indicating that the intensity of A. lumbricoides infection was lower in all the age ranges of the Cavacos population, especially among younger individuals, even six months after administration of the anthelminthic agent.


Asunto(s)
Albendazol/uso terapéutico , Antihelmínticos/uso terapéutico , Ascariasis/tratamiento farmacológico , Ascaris lumbricoides , Adolescente , Adulto , Animales , Ascariasis/epidemiología , Brasil , Niño , Femenino , Humanos , Masculino , Prevalencia , Población Rural
19.
Rev Soc Bras Med Trop ; 29(4): 373-6, 1996.
Artículo en Portugués | MEDLINE | ID: mdl-8768588

RESUMEN

We relate a case of an 18-year-old man, resident of Xapuri (state of Acre, Brazil), with a history of repeated episodes of meningoencephalitis (three in one year), each one was examined by a local doctor. In our service (Emílio Ribas Institute of Infectology) we observed a patient with polyjoint aches, radiological and bronchoscopic pulmonary alterations (without clinical features), meningeal and brain stem manifestations--with normal brain computed tomography and cerebrospinal fluid. Blood eosinophils and serological Toxocara canis test (ELISA) were greatly increased. With the hypothesis of Toxocariasis (visceral larva migrans) we administered thiabendazole that brought complete clinical and laboratory remission. Inspite of a new episode of headache with meningeal manifestation approximately one month later (treated with dexamethasone resulting in a full remission after three days) we have not found other manifestations in approximately three and a half years of ambulatory care.


Asunto(s)
Larva Migrans Visceral/diagnóstico , Toxocara canis , Adolescente , Animales , Anticuerpos Antihelmínticos/sangre , Antinematodos/administración & dosificación , Brasil , Enfermedad Crónica , Dexametasona/uso terapéutico , Glucocorticoides/uso terapéutico , Humanos , Larva Migrans Visceral/complicaciones , Larva Migrans Visceral/tratamiento farmacológico , Masculino , Recurrencia , Tiabendazol/administración & dosificación , Toxocara canis/inmunología
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