1.
Org Lett
; 15(16): 4054-7, 2013 Aug 16.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23927000
RESUMEN
A highly stereoselective one-pot reaction of aliphatic aldehydes and cyanoacrylamides has been developed. The one-pot reaction includes an organocatalytic Michael addition followed by an intramolecular hemiaminalization. After reduction, optically enriched 2-piperidinones with three contiguous chiral centers were obtained in up to 95% yield and 9:1 dr with 99% ee.