RESUMEN

A cosmid clone containing the entire human type II alpha 1 collagen gene (COL2A1) was used as probe in the Southern analysis of DNA from a panel of human/hamster somatic cell hybrids containing different portions of human chromosome 12. Two of the hybrids exhibited a similar terminal deletion q14.3----qter, but one was positive for the gene while the other was negative. Therefore, the gene must reside in the region q14.3.

Asunto(s)

Cromosomas Humanos Par 12 , Colágeno/genética , Genes , Animales , Línea Celular , Mapeo Cromosómico , Cricetinae , Citogenética , ADN , Humanos , Células Híbridas , Hibridación de Ácido Nucleico