RESUMEN

CF2H-Pseudoprolines obtained from difluoroacetaldehyde hemiacetal and serine are stable proline surrogates. The consequence of the incorporation of the CF2H group is an important decrease of the trans to cis amide bond isomerization energy and a remarkable stabilisation of the cis conformer by an hydrogen bond.

Asunto(s)

Péptidos/química , Prolina/análogos & derivados , Tiazoles/química , Tolueno/análogos & derivados , Enlace de Hidrógeno , Metilación , Conformación Molecular , Prolina/química , Estereoisomerismo , Tolueno/química