1.
Curr Org Synth
; 20(3): 278-307, 2023.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35366777
RESUMEN
BACKGROUND: 2-Hydroxy-1,4-Naphthoquinone (HNQ; Lawsone) is one of the most useful and the simplest naturally occurring naphthoquinones and has stimulated a resurgence of interest in the past decades due to a wide range of pharmacological activities. INTRODUCTION AND METHODS: This activity has led to the unusually large emphasis being placed on the design of more efficient multi-component reactions (MCRs) in the synthesis of bioactive lawsone derivatives. RESULTS AND CONCLUSION: This review highlights the recent developments in multi-component synthesis of biologically relevant naphthoquinone linked and fused heterocyclic derivatives carried out from 2015 till now.