RESUMEN
Top-level management teams are particularly exposed to stress factors as they frequently have to make important decision under stress. While an existing body of research evidence suggests that stress negatively affects decision-making processes, very little is known about possible strategies to reduce these negative effects. The aim of the current work is to investigate the effect of training self-regulation ability through neurobiofeedback on managers' intertemporal and risky decision making. Twenty-three managers were assigned to the experimental or the control condition. All participants performed, two decisional tasks, before and after a training phase. The tasks were administered through mouse tracker software, in order to measure participants' delay discounting and risk taking propensity on both explicit and implicit choice parameters. During the training phase, the experimental condition received a training protocol based on stress assessment tests via neurobiofeedback signals (i.e., temperature and skin conductance), with the goal of improving self-regulation ability while the control condition was administered a control training. The main result of this study is to have conclusively demonstrated that NBF training increases an individual's ability to self-regulate stress-related psychophysiological phenomena. Consequently, the improved ability to manage one's own reaction to stress enables a reduction in instinctive behavior during a probabilistic choice task.
Asunto(s)
Biorretroalimentación Psicológica/fisiología , Toma de Decisiones/fisiología , Aprendizaje , Autocontrol , Estrés Psicológico , Humanos , Aprendizaje/fisiología , Asunción de Riesgos , Estrés Psicológico/psicologíaRESUMEN
The goal of our research project is to develop a new class of orally active drugs, estrone sulfatase inhibitors, for the treatment of estrogen-dependent (receptor positive) breast cancer. Several compounds were synthesized and their pharmacological potencies explored. Based on encouraging preliminary results, three of them, TX 1299, TX 1492 and TX 1506 were further studied in vitro as well as in vivo. They proved to be strong inhibitors of estrone sulfatase when measured on the whole human JEG-3 choriocarcinoma and MCF-7 breast cancer cells and their IC(50)s found to be in the range of known standard inhibitors. Their residual estrogenic activity was checked as negative in the test of induction of alkaline phosphatase (APase) activity in whole human endometrial adenocarcinoma Ishikawa cells. In addition, their effect on aromatase activity in JEG-3 cells was also examined, since the goal of inhibiting both sulfatase and aromatase activities appears very attractive. However, it has been unsuccessful so far. Then, in vivo potencies of TX 1299, the lead compound in our chemical series, were evaluated in comparison with 6,6,7-COUMATE, a non-steroidal standard, in two different rat models and by oral route. First, the absence of any residual estrogenic activity for these compounds was checked in the uterotrophic model in prepubescent female rats. Second, antiuterotrophic activity in adult ovariectomized rat supplemented with estrone sulfate (E(1)S), showed that both compounds were potent inhibitors, the power of TX 1299 relative to 6,6,7-COUMATE being around 80%. This assay was combined with uterine sulfatase level determination and confirmed the complete inhibition of this enzyme within the target organ. Preliminary studies indicated that other non-steroid compounds in the Théramex series were potent in vitro and in vivo inhibitors of estrone sulfatase in rats and further studies are in progress.
Asunto(s)
Arilsulfatasas/antagonistas & inhibidores , Inhibidores Enzimáticos/farmacología , Estrógenos/metabolismo , Animales , Aromatasa/metabolismo , Cumarinas/farmacología , Relación Dosis-Respuesta a Droga , Neoplasias Endometriales/metabolismo , Femenino , Humanos , Concentración 50 Inhibidora , Ratas , Ratas Sprague-Dawley , Ratas Wistar , Esteril-Sulfatasa , Sulfatasas/metabolismo , Sulfonamidas/farmacología , Ácidos Sulfónicos , Células Tumorales Cultivadas , Útero/enzimología , Útero/metabolismoRESUMEN
The present and forthcoming applications of micro data processing in cardiology are reviewed. Heart signals benefit from the digital approach which reduces distortions and permits mass storage. Electrocardiography and, notably, Holter systems, as well as ultrasonic or radiological cardiac and vascular imaging begin to profit from these remarkable advances. Data banks will in due course be constituted which, among other things, will provide a better knowledge of the incidence of some diseases or pathological associations and of their natural history and course under treatment. Such banks will also form the basis of an objective evaluation of therapeutic effectiveness.